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. 1990 Nov;172(11):6581–6584. doi: 10.1128/jb.172.11.6581-6584.1990

Cloning of an aroF allele encoding a tyrosine-insensitive 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase.

L M Weaver 1, K M Herrmann 1
PMCID: PMC526849  PMID: 1977738

Abstract

In Escherichia coli, genes aroF+, aroG+, and aroH+ encode isoenzymes of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthases that are feedback inhibited by tyrosine, phenylalanine, and tryptophan, respectively. A single base pair change in aroF causes a Pro-148-to-Leu-148 substitution and results in a tyrosine-insensitive enzyme.

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Selected References

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