Table 1. Potential amino acid changes at WGCW hotspots.

Amino-acid	Abbr	U.total	U.norm	U.FW	U.CDR	M.total	M.norm	M.FW	M.CDR
Ala	A	13	16.0%	4	9	10	18.9%	7	3
Cys	C	5	6.2%	5	0	0	0.0%	0	0
Ile	I	0	0.0%	0	0	0	0.0%	0	0
Leu	L	13	16.0%	8	5	9	17.0%	7	2
Met	M	1	1.2%	1	0	1	1.9%	1	0
Phe	F	0	0.0%	0	0	0	0.0%	0	0
Trp	W	0	0.0%	0	0	0	0.0%	0	0
Val	V	0	0.0%	0	0	0	0.0%	0	0
Gly	G	0	0.0%	0	0	0	0.0%	0	0
His	H	2	2.5%	2	0	1	1.9%	1	0
Pro	P	0	0.0%	0	0	0	0.0%	0	0
Ser	S	26	32.1%	5	21	15	28.3%	3	12
Thr	T	0	0.0%	0	0	0	0.0%	0	0
Tyr	Y	0	0.0%	0	0	0	0.0%	0	0
Arg	R	0	0.0%	0	0	0	0.0%	0	0
Asn	N	0	0.0%	0	0	0	0.0%	0	0
Asp	D	0	0.0%	0	0	0	0.0%	0	0
Gln	Q	16	19.8%	14	2	14	26.4%	8	6
Glu	E	3	3.7%	0	3	0	0.0%	0	0
Lys	K	2	2.5%	0	2	3	5.7%	0	3