Table 2. Correlations between the expression of PD-Ls or tumor-infiltrating CD8+ lyphocytes and clinicopathological characteristics in ovarian carcinosarcoma (n = 19).
Variable | Intraepithelial PD-L1 expression | Mesenchymal PD-L1 expression | Intraepithelial CD8+ TIL | Mesenchymal CD8 + TIL | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
n | Negative | Positive | P | Negative | Positive | P | Negative | Positive | P | Negative | Positive | P | |
Age | 0.605 | 0.650 | 1.000 | 0.338 | |||||||||
<58 | 8 | 4 | 4 | 5 | 3 | 4 | 4 | 1 | 7 | ||||
≥58 | 11 | 6 | 5 | 5 | 6 | 6 | 5 | 4 | 7 | ||||
Stage | 0.800 | 0.528 | 0.528 | 1.000 | |||||||||
I | 2 | 1 | 1 | 2 | 0 | 0 | 2 | 0 | 2 | ||||
II | 5 | 2 | 3 | 3 | 2 | 3 | 2 | 1 | 4 | ||||
III | 12 | 7 | 5 | 5 | 7 | 7 | 5 | 4 | 8 | ||||
Histology subtype | 0.996 | 0.998 | 0.656 | 1.000 | |||||||||
Homologous | 9 | 5 | 4 | 5 | 4 | 4 | 5 | 2 | 7 | ||||
Heterologous | 10 | 5 | 5 | 5 | 5 | 6 | 4 | 3 | 7 | ||||
Menopause status | 0.087 | 0.906 | 0.303 | 1.000 | |||||||||
Premenopausal | 4 | 4 | 0 | 2 | 2 | 1 | 3 | 1 | 3 | ||||
Postmenopausal | 15 | 6 | 9 | 8 | 7 | 9 | 6 | 4 | 11 | ||||
Pretreatment CA125 | 0.588 | 1.000 | 1.000 | 1.000 | |||||||||
≤ 200 U/ml | 4 | 3 | 1 | 2 | 2 | 2 | 2 | 1 | 3 | ||||
> 200 U/ml | 14 | 7 | 7 | 7 | 7 | 8 | 6 | 4 | 10 | ||||
Ascitic fluid | 0.020 | 0.650 | 1.000 | 0.603 | |||||||||
Negative | 12 | 9 | 3 | 7 | 5 | 6 | 6 | 4 | 8 | ||||
Positive | 7 | 1 | 6 | 3 | 4 | 4 | 3 | 1 | 6 | ||||
Tumor site | 0.303 | 0.141 | 1.000 | 0.084 | |||||||||
Unilateral | 14 | 6 | 8 | 9 | 5 | 7 | 7 | 2 | 12 | ||||
Bilateral | 5 | 4 | 1 | 1 | 4 | 3 | 2 | 3 | 2 | ||||
Tumor volume | 0.370 | 0.650 | 1.000 | 0.338 | |||||||||
≤ 12 cm | 11 | 7 | 4 | 5 | 6 | 6 | 5 | 4 | 7 | ||||
> 12cm | 8 | 3 | 5 | 5 | 3 | 4 | 4 | 1 | 7 | ||||
Residual tumor | 0.350 | 0.650 | 0.350 | 1.000 | |||||||||
R0 | 12 | 5 | 7 | 7 | 5 | 5 | 7 | 3 | 9 | ||||
Visible residual disease | 7 | 5 | 2 | 3 | 4 | 5 | 2 | 2 | 5 | ||||
Chemotherapy | 0.608 | 0.608 | 1.000 | 1.000 | |||||||||
PTX+CBP | 10 | 4 | 6 | 4 | 6 | 5 | 5 | 3 | 7 | ||||
IFO/DOX | 5 | 3 | 2 | 3 | 2 | 3 | 2 | 2 | 3 |
R0 = no visible disease after cytoreductive surgery. PTX = Paclitaxel; CBP = Carboplatin; IFO = Ifosfamide; DOX = Doxorubicin