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. 2017 Jan 26;12(1):e0170879. doi: 10.1371/journal.pone.0170879

Table 2. Correlations between the expression of PD-Ls or tumor-infiltrating CD8+ lyphocytes and clinicopathological characteristics in ovarian carcinosarcoma (n = 19).

Variable Intraepithelial PD-L1 expression Mesenchymal PD-L1 expression Intraepithelial CD8+ TIL Mesenchymal CD8 + TIL
n Negative Positive P Negative Positive P Negative Positive P Negative Positive P
Age 0.605 0.650 1.000 0.338
        <58 8 4 4 5 3 4 4 1 7
        ≥58 11 6 5 5 6 6 5 4 7
Stage 0.800 0.528 0.528 1.000
        I 2 1 1 2 0 0 2 0 2
        II 5 2 3 3 2 3 2 1 4
        III 12 7 5 5 7 7 5 4 8
Histology subtype 0.996 0.998 0.656 1.000
        Homologous 9 5 4 5 4 4 5 2 7
        Heterologous 10 5 5 5 5 6 4 3 7
Menopause status 0.087 0.906 0.303 1.000
        Premenopausal 4 4 0 2 2 1 3 1 3
        Postmenopausal 15 6 9 8 7 9 6 4 11
Pretreatment CA125 0.588 1.000 1.000 1.000
        ≤ 200 U/ml 4 3 1 2 2 2 2 1 3
        > 200 U/ml 14 7 7 7 7 8 6 4 10
Ascitic fluid 0.020 0.650 1.000 0.603
    Negative 12 9 3 7 5 6 6 4 8
    Positive 7 1 6 3 4 4 3 1 6
Tumor site 0.303 0.141 1.000 0.084
    Unilateral 14 6 8 9 5 7 7 2 12
    Bilateral 5 4 1 1 4 3 2 3 2
Tumor volume 0.370 0.650 1.000 0.338
    ≤ 12 cm 11 7 4 5 6 6 5 4 7
    > 12cm 8 3 5 5 3 4 4 1 7
Residual tumor 0.350 0.650 0.350 1.000
    R0 12 5 7 7 5 5 7 3 9
    Visible residual disease 7 5 2 3 4 5 2 2 5
Chemotherapy 0.608 0.608 1.000 1.000
    PTX+CBP 10 4 6 4 6 5 5 3 7
    IFO/DOX 5 3 2 3 2 3 2 2 3

R0 = no visible disease after cytoreductive surgery. PTX = Paclitaxel; CBP = Carboplatin; IFO = Ifosfamide; DOX = Doxorubicin