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. 2017 Jan 26;12(1):e0170999. doi: 10.1371/journal.pone.0170999

Fig 4. Functional assays on miR-21-5p-transfected MPM cell lines.

Fig 4

The columns represent mean values, the bars show SEM of three independent experiments. (A) SRB proliferation assay in Mero-14 (left) and MSTO-211H (right) treated with 30 nM of miR-21-5p mimic or negative control mimic. Asterisk (*) indicates P < 0.05 according to Bonferroni multiple comparison test within the mANOVA model. (B) Clonogenic assay: representative image of colonies formed by negative control (NC) or miR-21-5p transfected (100 nM) Mero-14 (left) and MSTO-211H (right) cell lines. The number of colonies is reported in % compared to the average of the three wells transfected with negative control in each experiment. The P-value according to Student’s t-test is reported.