Table 1.
Immunohistochemistry and molecular features of 36 human serrated morphology CRCs.
CDX2 (+) |
CDX2 (-) |
*p value |
BRAF mut |
BRAF wt |
*p value |
|
|---|---|---|---|---|---|---|
|
Immunohistochemistry |
||||||
MUC5AC(+) |
2 |
15 |
0.0008 |
11 |
6 |
0.335 |
MUC5AC(-) |
13 |
6 |
9 |
10 |
||
MUC6(+) |
0 |
6 |
0.031 |
6 |
1 |
0.104 |
MUC6(-) |
15 |
15 |
14 |
15 |
||
MUC2(+) |
9 |
17 |
0.260 |
13 |
13 |
0.456 |
MUC2(-) |
6 |
4 |
7 |
3 |
||
MLH1 retained |
14 |
18 |
0.626 |
16 |
16 |
0.113 |
MLH1 loss |
1 |
3 |
4 |
0 |
||
MSH2 retained |
15 |
21 |
20 |
16 |
||
MSH2 loss |
0 |
0 |
0 |
0 |
||
β-catenin membranous |
4 |
13 |
0.049 |
14 |
3 |
0.003 |
β-catenin nucleus |
11 |
8 |
6 |
13 |
||
p53 mut |
8 |
13 |
0.736 |
15 |
6 |
0.052 |
p53 wt |
7 |
8 |
5 |
10 |
||
p16 retained |
11 |
7 |
0.041 |
7 |
11 |
0.092 |
p16 loss |
4 |
14 |
13 |
5 |
||
Annexin A10 (+) |
6 |
18 |
0.010 |
20 |
4 |
1.4 × 10−6 |
Annexin A10 (-) |
9 |
3 |
0 |
12 |
||
|
Molecular features |
||||||
MSI |
1 |
4 |
0.376 |
4 |
1 |
0.355 |
MSS |
14 |
17 |
16 |
15 |
||
CIMP phenotype (+) |
2 |
10 |
0.040 |
11 |
1 |
0.004 |
CIMP phenotype (-) |
13 |
11 |
9 |
15 |
||
Total |
15 |
21 |
20 |
16 |
*p values are from Fisher’s exact test.