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. Author manuscript; available in PMC: 2017 Jan 26.
Published in final edited form as: Gene. 2015 Jun 14;570(1):1–7. doi: 10.1016/j.gene.2015.06.031

Tab. 1.

P2X and P2Y receptors and their roles in bone development and homeostasis

Receptor Nucleotide binding G-protein coupling skeletal development related functions, phenotypes References
P2X1 ATP negative regulation of bone mineralization [83]
P2X2 ATP
P2X3 ATP expressed in human MSCs [56]
P2X4 ATP SNP associates with an increased risk for osteoporosis [72]
P2X5 ATP expressed in human MSCs and osteoblasts [56]
P2X6 ATP upregulated in adipocytes, low expressed in osteoblasts [56]
P2X7 ATP Important role in bone development and homeostasis [63, 70, 71, 74–77]
P2Y1 ADP Gq/11 decreased bone mass in P2Y1−/− mice [84]
P2Y2 ATP, ADP Gq/11 increased bone mass in P2Y2−/− mice [84]
P2Y4 UTP Gi and Gq/11
P2Y6 UDP Gq/11 decreased bone resorption in P2Y6−/− mice [85]
P2Y11 ATP Gs and Gq/11
P2Y12 ADP Gi Important mediator of normal bone maintenance [86, 87]
P2Y13 ADP Gi decreased bone formation and bone resorption in P2Y13−/− mice [84]
P2Y14 UDP-glucose Gi