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. 2017 Jan 26;5(2):e13084. doi: 10.14814/phy2.13084

Figure 1.

Figure 1

SBP measurements by tail cuff in (A) nonlupus mice treated with vehicle alone (control + vehicle, n = 6), (B) nonlupus mice treated with Ac‐SDKP (control + Ac‐SDKP, n = 6), (C) lupos mice treated with vehicle (SLE + vehicle, n = 10), and (D) lupus mice treated with Ac‐SDKP (SLE + Ac‐SDKP, n = 10). Blood pressure was monitored weekly from 25 to 38 weeks of age. Vehicle or Ac‐SDKP (800 μg/kg per day) were infused via osmotic minipump from the age of 25 weeks. The recording of each individual mouse SBP is represented in different colors and the mouse ID number is shown at the figure inset. Some of the SLE mice developed a very aggressive and acute form of hypertension (SBP >140 mmHg) that was followed by death. The time of the manifestation of the acute hypertension manifestation in vehicle‐treated SLE‐Hyp mice occurred from 27 to 29 weeks of age, whereas in Ac‐SDKP‐treated animals, it occurred between 32 and 35 weeks of age. SBP, systolic blood pressure; Ac‐SDKP, N‐acetyl‐seryl‐aspartyl‐lysyl‐proline; SLE, systemic lupus erythematosus.