Table 1.
Ac‐SDKP effects on body weight, anti‐dsDNA IgG, kidney weight, and interstitial collagen deposition in Ctl and SLE mice treated with veh or Ac‐SDKP (800 μg/kg per day)
| Ctl + veh | Ctl + Ac‐SDKP | SLE + Veh | SLE + Ac‐SDKP | |
|---|---|---|---|---|
| Body weight (g) | 33.2 ± 1.0 | 32.5 ± 0.9 | 41.3 ± 0.9a | 39.7 ± 1.5 |
| Anti‐dsDNA IgG (kU/mL) | 13.1 ± 2.8 | 93.4 ± 31.1 | 137.5 ± 68.9 | 82.6 ± 25.3 |
| Kidney weight (mg) | 194 ± 7 | 194 ± 9 | 228 ± 7 | 219 ± 10 |
| Kidney weight corrected by body weight (mg/g) | 5.8 ± 0.2 | 5.9 ± 0.2 | 5.6 ± 0.1 | 5.8 ± 0.3 |
| Interstitial collagen deposition (% of area) | 4.2 ± 0.5 | 4.0 ± 0.5 | 4.6 ± 0.4 | 4.7 ± 0.5 |
Values are means ± SE. Ac‐SDKP, N‐acetyl‐seryl‐aspartyl‐lysyl‐proline; Ctl, control; SLE, systemic lupus erythematosus; Veh, vehicle.
a
P < 0.01 Ctl + veh versus SLE + veh.