Table 3.

Diastolic function in control and IUGR offspring at 21 weeks of age

	Control		IUGR
Measurement	HF Diet	HF Diet + R	HF Diet	HF Diet + R	IUGR	Diet	Int
Male offspring
E, mm/s	1026.1 ± 51.2	1021 ± 14.3	898.9 ± 44.1	810.9 ± 56.9	**
A, mm/sec	904.7 ± 49.0	926.2 ± 37.4	757.5 ± 59.8	740.5 ± 71.0	**
E/A	1.11 ± 0.01	1.07 ± 0.02	1.22 ± 0.12	1.10 ± 0.04
DT, msec	34.6 ± 3.6	43.5 ± 1.7	45.7 ± 3.8	47.6 ± 1.6	*
IVRT, msec	22.4 ± 1.0	20.5 ± 0.8	25.3 ± 0.5	26.0 ± 1.5	***
MPI	0.66 ± 0.02	0.62 ± 0.03	0.69 ± 0.02	0.74 ± 0.06
E’, mm/sec	40.8 ± 3.9	39.9 ± 4.1	35.2 ± 4.4	35.2 ± 2.3
A’, mm/sec	44.7 ± 4.5	41 ± 4.4	40.3 ± 5.0	37.8 ± 3.3
E’/A’	0.92 ± 0.03	0.98 ± 0.01	0.88 ± 0.04	0.95 ± 0.06
E/E’	25.7 ± 1.5	26.9 ± 3.4	28.8 ± 6.8	23.4 ± 2.5
Female offspring
E, mm/sec	901.1 ± 83.0	906.1 ± 47.3	972.7 ± 75.4	788.2 ± 52.5
A, mm/sec	684.9 ± 94.8	786.1 ± 40.9	756.2 ± 101	663.8 ± 61.7
E/A index	1.36 ± 0.1	1.16 ± 0.04	1.32 ± 0.1	1.20 ± 0.09
DT, msec	45.3 ± 1.3	39.5 ± 1.0	40.0 ± 2.8	43.1 ± 2.5			*
IVRT, msec	23.0 ± 1.0	22.6 ± 0.5	24.3 ± 1.5	26.2 ± 1.2	*
MPI	0.69 ± 0.02	0.74 ± 0.03	0.65 ± 0.05	0.68 ± 0.04
E’, mm/sec	36.4 ± 2	35.7 ± 4.8	36 ± 2.6	37.1 ± 5.7
A’, mm/sec	38.4 ± 2.7	37.7 ± 4.0	40.1 ± 4.0	36.2 ± 3.8
E’/A’	0.96 ± 0.05	0.94 ± 0.04	0.91 ± 0.04	0.97 ± 0.07
E/E’	25.3 ± 3.3	27.3 ± 3.8	27.4 ± 2.9	22.5 ± 2.8

Values are expressed as mean ± SEM (n = 5 per group). All groups were compared using a two‐way ANOVA followed by a Bonferroni post hoc test.

HF, high‐fat; R, resveratrol; IUGR, intrauterine growth restriction; Int, interaction; E, peak velocity of early mitral inflow; A, peak velocity of late mitral inflow; DT, deceleration time; IVRT, isovolumic relaxation time; MPI, myocardial performance index; E’, early diastolic velocity of mitral annulus; A’, late diastolic velocity of mitral annulus.

*P < 0.05, **P < 0.01, ***P < 0.001 for differences in the main effect (IUGR or resveratrol) or their interaction.

Bold indicates parameters that have significant effect of source of variation (IUGR or Resv) or their interaction.