Table 3.
Association between rs1052632 and clinical subtypes of tuberculosis. We combined the discovery and validation cohorts and included an additional 450 subjects with pulmonary tuberculosis. We analyzed the association of rs1052632 with either pulmonary (PTB) or meningeal (TBM) tuberculosis using both genotypic and recessive models. Odds ratios (OR) and unadjusted p-values of significance are highlighted.
| GenotypicAnalysis | Recessive Analysis | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP | Group | HWE | AA | Aa | aa | z | p-value | AA+Aa | aa | chi2 | p-value | OR | CI |
| rs1052632 | CTRL | 0.68 | 509 (0.68) | 219 (0.29) | 26 (0.03) | 728 (0.97) | 26 (0.03) | ||||||
| PTB | 528 (0.66) | 234 (0.29) | 41 (0.05) | 1.19 | 0.235 | 762 (0.95) | 41 (0.05) | 2.59 | 0.1072 | 1.51 | (0.89-2.59) | ||
| TBM | 176 (0.63) | 77 (0.28) | 27 (0.1) | 2.66 | 0.008 | 253 (0.9) | 27 (0.1) | 16.11 | 0.0001 | 2.99 | (1.64-5.43) | ||