Table 1.
Clinical and biochemical characteristics of the study population
| Parameter | Age quartiles | ||||
|---|---|---|---|---|---|
| 19–35 (n = 48) | 36–50 (n = 47) | 51–65 (n = 48) | 66–80 (n = 48) | p value | |
| Male [n (%)] | 24 (50 %) | 22 (47.8 %) | 35 (72.9 %) | 25 (52.1 %) | 0.332 |
| IR [n (%)] | 9 (18.8 %) | 13 (27.7 %) | 14 (29.2 %) | 16 (33.3 %) | 0.116 |
| BMI (kg/m2) | 21.24 ± 2.79 | 24.10 ± 3.36 | 24.48 ± 2.56 | 24.22 ± 2.80 | <0.001 |
| Waist–hip ratio | 0.81 ± 0.65 | 0.83 ± 0.10 | 0.87 ± 0.85 | 0.87 ± 0.10 | 0.002 |
| SBP (mmHg) | 117 ± 12 | 130 ± 8 | 127 ± 8 | 128 ± 9 | <0.001 |
| DBP (mmHg) | 72 ± 10 | 82 ± 9 | 80 ± 9 | 75 ± 10 | <0.001 |
| TC (mmol/L) | 4.41 ± 1.02 | 4.82 ± 1.12 | 4.67 ± 1.00 | 4.68 ± 0.83 | 0.250 |
| HDL-C (mmol/L) | 1.26 ± 0.31 | 1.22 ± 0.31 | 1.19 ± 0.25 | 1.13 ± 0.20 | 0.203 |
| LDL-C (mmol/L) | 2.51 ± 0.76 | 2.78 ± 0.73 | 2.66 ± 0.69 | 2.64 ± 0.63 | 0.300 |
| TG (mmol/L) | 1.21 ± 0.69 | 1.64 ± 0.81 | 1.50 ± 0.78 | 1.48 ± 0.66 | 0.041 |
| FPG (mmol/L) | 4.70 ± 0.64 | 5.32 ± 0.70 | 5.25 ± 0.74 | 5.14 ± 0.77 | <0.001 |
| WBC (×109/L) | 6.07 ± 1.24 | 5.81 ± 1.34 | 6.63 ± 1.51 | 6.41 ± 1.71 | 0.035 |
| hsCRP (mg/L) | 3.73 ± 2.05 | 6.69 ± 5.57 | 6.54 ± 5.93 | 6.59 ± 6.08 | 0.882 |
| ALT (U/L) | 14.82 ± 7.50 | 21.67 ± 15.80 | 26.26 ± 18.44 | 19.60 ± 13.21 | 0.002 |
| BUN (mmol/L) | 6.17 ± 8.32 | 6.85 ± 10.33 | 5.77 ± 1.19 | 6.73 ± 5.62 | 0.870 |
| Cr (mg/L) | 71.54 ± 30.64 | 76.72 ± 51.97 | 84.37 ± 47.74 | 85.22 ± 37.58 | 0.343 |
| uric acid (mg/L) | 312.45 ± 91.77 | 298.64 ± 108.06 | 350.99 ± 94.36 | 369.77 ± 110.61 | 0.002 |
| Vaspin (ng/mL) | 1.01 ± 2.25 | 1.67 ± 2.95 | 2.06 ± 3.49 | 2.40 ± 3.06 | 0.123 |
| Adiponectin (μg/mL) | 8.95 ± 5.76 | 10.45 ± 11.26 | 10.985 ± 6.34 | 16.78 ± 9.34 | <0.001 |
| Insulin (uIU/mL) | 9.20 ± 5.32 | 9.47 ± 4.20 | 9.65 ± 3.86 | 10.30 ± 3.34 | 0.625 |
| HOMA-IR | 1.90 ± 1.06 | 2.26 ± 1.096 | 2.24 ± 0.93 | 2.35 ± 0.83 | 0.131 |
Continuous variables were described as mean ± SD; categorical variables were presented as frequencies
SBP systolic blood pressure, DBP diastolic blood pressure, n number of patients, BMI body mass index, LDL-C low-density lipoprotein cholesterol, HDL-C high-density lipoprotein cholesterol, TG triglycerides, TC total cholesterol, FPG fasting plasma glucose, ALT alanine aminotransferase, BUN blood urea nitrogen, Cr serum creatinine concentrations, WBC white blood cells count, hsCRP high-sensitive CRP, HOMA-IR homoeostasis model of assessment–insulin resistance