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. 2016 Sep 20;28(2):559–566. doi: 10.1007/s00198-016-3764-7

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© The Author(s) 2016

Open Access This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — a Change in BMD at lumbar spine. In both groups, lumbar BMD values increased significantly from before 2 years to after 1 year of denosumab treatment (P < 0.001). However, BMD values in the non-responsive group did not reach those in the BP-responsive group at 1 year of denosumab therapy (P = 0.080). b Change in BMD at hips. In the non-responsive group, BMD values were significantly decreased (P < 0.001) after 2 years of BP treatment. After denosmab treatment, hip BMD values increased in both groups to a comparable degree (P = 0.709). As a result, BMD values in the non-responsive group were lower than those in the responsive group at 1 year of denosumab treatment (P = 0.065).