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. Author manuscript; available in PMC: 2018 Jan 25.
Published in final edited form as: Cell Syst. 2016 Nov 17;4(1):46–59.e4. doi: 10.1016/j.cels.2016.10.014

Figure 6.

Figure 6

MARK3 expression in multiple tissues is regulated by the same variants associated with BMD. A). H3K4me2 and H3K27ac modifications in primary human osteoblasts across the Chr. 14q32.32 association. Local eQTL influencing B) MARK3 expression in thyroid tissue, C) CKB expression skeletal muscle and D) TRMT61A expression in aorta. In B-D, PP4 is the posterior probability that the eQTL and BMD associations share a single common variant and PP3 is the posterior probability for the region harboring two independent variants, each affecting either gene expression or BMD. E) Effect of the “T” allele of rs11623869 (lead GWAS SNP at the Chr. 14q32.32 locus) on BMD (in red) and the expression of MARK3 in multiple tissues.