TABLE 1.
OFM genes.
| GWAS SNP | Chr | SNP Position (Mbp) | Gene | Gene Position (Mbp) | Modulea | Groupb | Novelc | Referenced |
|---|---|---|---|---|---|---|---|---|
| rs7521902 | 1 | 22.164 | WNT4 | 22.143 | 9 | OFM_9 | NO | 25108526, 25108526 |
| rs6426749 | 1 | 22.385 | WNT4 | 22.143 | 9 | OFM_9 | NO | 25108526, 25108526 |
| rs17482952 | 1 | 68.174 | WLS | 68.233 | 9 | OFM_9 | NO | 22745162, 22745162 |
| rs12407028 | 1 | 68.182 | WLS | 68.233 | 9 | OFM_9 | NO | 22745162, 22745162 |
| rs479336 | 1 | 172.230 | DNM3OS | 172.145 | 6 | OFM_6 | NO | 18985749, NA |
| rs4233949 | 2 | 54.433 | SPTBN1 | 54.456 | 6 | OFM_6 | YES | NA |
| rs17040773 | 2 | 111.742 | MERTK | 111.899 | 0 | OFM_R | YES | NA |
| rs1346004 | 2 | 165.745 | GALNT3 | 165.794 | 0 | OFM_R | NO | 22912827, 25899975 |
| rs6532023 | 4 | 87.853 | MEPE | 87.821 | 6 | OFM_6 | NO | 12421822, 12421822 |
| rs1366594 | 5 | 89.080 | MEF2C | 88.904 | 6 | OFM_6 | NO | 17336904, 21652706 |
| rs13245690 | 7 | 121.145 | CPED1 | 120.989 | 6 | OFM_6 | YES | NA |
| rs13245690 | 7 | 121.145 | WNT16 | 121.325 | 6 | OFM_6 | NO | 25306234, 25306234 |
| rs3801387 | 7 | 121.335 | FAM3C | 121.396 | 6 | OFM_6 | YES | NA |
| rs3801387 | 7 | 121.335 | WNT16 | 121.325 | 6 | OFM_6 | NO | 25306234, 25306234 |
| rs2062377 | 8 | 118.995 | SAMD12 | 118.622 | 0 | OFM_R | YES | NA |
| rs2062377 | 8 | 118.995 | TNFRSF11B | 118.952 | 9 | OFM_9 | NO | 9108485, 9950424 |
| rs7851693 | 9 | 130.603 | FUBP3 | 130.580 | 0 | OFM_R | YES | NA |
| rs1373004 | 10 | 52.668 | DKK1 | 52.314 | 6 | OFM_6 | NO | 16753024, 16753024 |
| rs7071206 | 10 | 77.642 | KCNMA1 | 77.638 | 6 | OFM_6 | YES | NA |
| rs7071206 | 10 | 77.642 | DLG5 | 77.927 | 9 | OFM_9 | YES | NA |
| rs7108738 | 11 | 15.689 | INSC | 15.112 | 9 | OFM_9 | YES | NA |
| rs7932354 | 11 | 46.701 | LRP4 | 46.919 | 9 | OFM_9 | NO | 25733894, 25733894 |
| rs3736228 | 11 | 68.434 | LRP5 | 68.313 | 9 | OFM_9 | NO | 11956231, 11956231 |
| rs3736228 | 11 | 68.434 | PPP6R3 | 68.461 | 0 | OFM_R | YES | NA |
| rs2887571 | 12 | 1.529 | WNT5B | 1.617 | 6 | OFM_6 | NO | 26273529, NA |
| rs2016266 | 12 | 53.334 | SP7 | 53.345 | 9 | OFM_9 | NO | 11792318, 11792318 |
| rs736825 | 12 | 54.024 | HOXC6 | 54.017 | 6 | OFM_6 | NO | 1100234, NA |
| rs1053051 | 12 | 106.973 | TMEM263 | 106.956 | 3 | OFM_R | YES | NA |
| rs11623869 | 14 | 103.417 | MARK3 | 103.385 | 0 | OFM_R | YES | NA |
| rs1564981 | 16 | 50.952 | CYLD | 50.742 | 0 | OFM_R | NO | 18382763, NA |
| rs1566045 | 16 | 50.988 | CYLD | 50.742 | 0 | OFM_R | NO | 18382763, NA |
| rs4790881 | 17 | 2.166 | HIC1 | 2.055 | 0 | OFM_R | YES | NA |
| rs4790881 | 17 | 2.166 | SMG6 | 2.304 | 0 | OFM_R | YES | NA |
| rs4792909 | 17 | 43.721 | MEOX1 | 43.662 | 6 | OFM_6 | NO | 12538525, NA |
| rs4792909 | 17 | 43.721 | SOST | 43.759 | 6 | OFM_6 | NO | 11181578, 15024046 |
| rs227584 | 17 | 44.148 | HDAC5 | 44.124 | 1 | OFM_R | NO | 25271055, 19920351 |
| rs3790160 | 20 | 10.659 | BTBD3 | 11.891 | 6 | OFM_6 | YES | NA |
a
Coexpression network module from (Calabrese et al. Plos Genetics).
b
OFM gene group, OFM_6 = member of module 6, OFM_9 = member of module 9 and OFM_R = not a member of module 6 or 9, but expression was highly correlated with the module 6 or 9 eigengene.
c
Whether or not a gene is known to be involved in the regulation of BMD and/or osteoblast activity.
d
Reference PMID number demonstrating a known gene is involved in BMD (first #) and osteoblast activity (second #).