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. Author manuscript; available in PMC: 2018 Jan 25.
Published in final edited form as: Cell Syst. 2016 Dec 15;4(1):60–72.e4. doi: 10.1016/j.cels.2016.11.006

Fig. 3. BLSA protein modules correlate to cognitive status and AD neuropathological burden.

Fig. 3

(A) BLSA protein modules were clustered to assess module relatedness based on correlation of protein co-expression eigenproteins. Pearson correlation and P value between module eigenprotein expression and CERAD (top) and Braak (bottom). (B) Module expression profiles and key hub proteins that are positively correlated with CERAD and/or Braak. (C) Module expression profiles and key hub proteins that are negatively correlated with CERAD and/or Braak. Box plots with error bars are displayed for each of the three groups of case samples (control, AsymAD and AD). Significance was measured using one-way nonparametric ANOVA, Kruskal-Wallis p-values. Cell type associated modules are encircled (dashed line).