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. Author manuscript; available in PMC: 2017 May 8.
Published in final edited form as: Gene Ther. 2016 Nov 8;24(1):31–39. doi: 10.1038/gt.2016.73

Figure 4.

Figure 4

PDGF gene therapy and PEI vector inhibit bone bridging length across the defect and new bone area within the defect. Histomorphometric analysis is shown for bridge length (mm) across the defect (a) and bridging bone as percent of original defect length (b). Area measurements include new bone within surgically-created defect in mm2 (c), defect fill as percentage of original defect area (d), and total new bone (mm2), including that external to the original defect (e). Significant differences between groups were assessed by one-way analysis of variance followed by Tukey's post-test (*p<0.05, ** p<0.01, ***p<0.001, ****p < 0.0001). Values are expressed as mean ± SEM.