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. 2016 Jul 26;22(10):1440–1447. doi: 10.1038/mp.2016.118

Figure 4.

Figure 4

p11 overexpression in D2R-containing PrL neurons ameliorates stress-induced behavioral and glutamatergic synaptic deficits. (a–d) Depression-like behaviors in control and stressed D2-Cre mice with the expression of AAV_p11 or AAV_eYFP in D2R-containing PrL neurons, as measured by TST (a), FST (b), SPT (c) and NSF (d) (n=10 CON(D2)+AAV_eYFP, CON(D2)+AAV_p11; n=12 RST(D2)+AAV_eYFP; n= 14 RST(D2)+AAV_p11). *P<0.05, **P<0.01, one-way analysis of variance. (e and g) Summarized input–output curves of AMPAR-EPSC (e) and NMDA-EPSC (g) in D2+ layer II/III PrL neurons from control mice (D2-tdT) and RST mice with PrL injection of AAV_eYFP or AAV_p11 (e, n=21 CON(D2), n=26 RST(D2), n=14 RST(D2)+AAV_eYFP, n=22 RST(D2)+AAV_p11; g, n=13 CON(D2), n=13 RST(D2), n=15 RST(D2)+AAV_eYFP, n=12 RST(D2)+AAV_p11]. (f and h) Representative AMPAR-EPSC (f) and NMDAR-EPSC (h) traces in different groups. **P<0.01, ***P<0.001, RST(D2) vs CON(D2); #P<0.05, ##P<0.01, ###P<0.001, RST(D2)+AAV_p11 vs RST(D2)+AAV_eYFP, two-way analysis of variance (e and g). CON(D2), control D2-Cre mice; RST(D2), D2-Cre mice exposed to chronic restraint stress. Data are means±s.e.m. FST, forced swin test; NSF, novelty-supressed feeding; PrL, prelimbic cortex; SPT, sucrose preference test; TST, tail suspension test.

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