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. 2017 Jan 27;7:41240. doi: 10.1038/srep41240

Figure 4. Enhanced resistance to M. tuberculosis infection after airway allergen challenge is critically dependent on IL-33 receptor ST2.

Figure 4

BMDMs were differentiated into M0, M1 or M2 macrophages and stimulated with Poly IC (5 μg/mL). After 24 hours, IL-33 production was evaluated (a). The data represent the mean ± s.e.m. from 1 independent experiment (n = 3) *p < 0.05. BALB/c and ST2KO mice were infected with M. tuberculosis and then sensitized and challenged with OVA, as depicted in Fig. 1a. The CFU number (b), gene expression (c,d) and the CD11c+CD206+ cell population (e) were evaluated in the lungs of only-infection WT or ST2KO mice and in the lungs of infected WT or ST2KO mice exposed to allergen. The data represent the mean ± s.e.m. from 2 independent experiments (n = 6–13). *p < 0.05.