Table 2. Association between a general haplotype including all 18 common LRRK2 variants and risk of CBD.
| Haplotype | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||||||||||||
| Variant | Amino acid | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 |
| rs10878245 | L153L | C | T | T | C | C | C | C | C | C | T | T | T | T | T | T | C | C | T |
| rs7308720 | N551K | C | C | C | C | C | G | C | C | C | C | C | C | G | C | C | C | C | C |
| rs10878307 | I723V | A | A | A | A | A | A | A | A | G | A | A | A | A | A | A | A | A | G |
| rs7966550 | L953L | T | T | T | T | T | T | T | T | T | C | T | T | T | T | T | T | T | T |
| rs7133914 | R1398H | G | G | G | G | G | A | G | G | G | G | G | G | A | G | G | G | G | G |
| rs11175964 | K1423K | G | G | G | G | G | A | G | G | G | G | G | G | A | G | G | G | G | G |
| rs35507033 | R1514Q | G | G | G | G | G | G | G | G | G | G | G | G | G | G | G | G | G | G |
| rs33958906 | P1542S | C | C | T | C | C | C | C | C | C | C | C | C | C | C | C | C | C | C |
| rs1427263 | G1624G | A | C | A | A | A | A | C | A | C | C | A | A | A | A | A | A | A | C |
| rs11176013 | K1637K | G | A | A | G | G | G | A | G | A | A | G | A | G | G | G | G | G | A |
| rs35303786 | M1646T | T | T | T | T | T | T | T | T | T | T | T | T | T | T | T | T | T | T |
| rs11564148 | S1647T | T | T | T | T | A | T | T | A | T | T | T | T | T | T | A | T | T | T |
| rs10878371 | G1819G | C | T | T | C | C | C | T | C | T | T | C | T | C | C | C | C | C | T |
| rs33995883 | N2081D | A | A | A | A | A | A | A | A | A | A | A | A | A | G | A | A | A | A |
| rs10878405 | E2108E | G | G | G | A | G | G | G | A | G | G | G | G | G | G | A | G | A | G |
| rs33962975 | G2385G | A | A | G | A | G | A | A | A | A | A | A | G | A | A | A | A | A | A |
| rs3761863 | M2397T | C | T | C | C | C | C | T | C | T | T | C | C | C | T | C | C | C | T |
| rs76904798 | N/A | T | C | C | T | C | C | C | C | C | C | C | C | C | T | C | C | C | C |
| % in CBD | 3.3 | 1.8 | 1.1 | 1.9 | 3.4 | 0.9 | 7.3 | 22.1 | 3.9 | 10.4 | 0.7 | 7.3 | 5.7 | 2.2 | 2.3 | 3.4 | 2.3 | 4.0 | |
| % in controls | 6.0 | 4.2 | 2.3 | 3.4 | 4.3 | 1.7 | 8.2 | 23.3 | 4.9 | 10.7 | 1.0 | 6.0 | 5.2 | 1.6 | 1.4 | 2.2 | 1.1 | 1.8 | |
| P-value | 0.024 | 0.17 | 0.20 | 0.20 | 0.38 | 0.40 | 0.45 | 0.47 | 0.71 | 0.87 | 0.86 | 0.63 | 0.58 | 0.44 | 0.30 | 0.25 | 0.033 | 0.016 | |
P-values result from score tests for association.