Figure 1. CIRP contributes to systemic injury in sepsis.

At 20 h after CLP, serum levels of (A) AST (colorimetry) and (B) IL-6 (ELISA) were elevated in septic WT mice (*P < 0.05 vs. sham WT mice) and significantly reduced in septic CIRP KO mice (^#P < 0.05 vs. septic WT mice). Data are expressed as last square mean ± SEM. Sample sizes: AST, sham WT = 4, CLP WT = 8, sham CIRP KO = 4, CLP CIRP KO = 8; IL-6, WT = 5, CLP WT = 6, sham CIRP KO = 4, CLP CIRP KO = 7.