Figure 7. Dendritic spine density of the D₁, D₂ and D₁/D₂ MSNs in sham and 6-OHDA-lesioned mice.

Sholl analysis of spine density (left column) and histograms showing the overall spine density (center column) of the D₁ ((a), red), D₂ ((b), green) and D₁/D₂ ((c), yellow) striatal MSNs in sham (circles and plain columns) and 6-OHDA (square and hatched columns) lesioned mice. The right column provides representative examples of dendritic segments belonging to the D₁, D₂ or D₁/D₂ MSNs that were filled with Lucifer yellow in sham and 6-OHDA-lesioned mice. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 for sham vs. 6-OHDA by a Student’s T-test (histograms) or Two-way ANOVA followed by Bonferroni’s multiple comparison test (Sholl analysis).