Figure 8. D1/D2 double BAC transgenic mice.
Confocal images from the Drd1a-tdTomato/Drd2-EGFP double BAC transgenic mice (D1/D2) in which the expression of a red fluorescent protein (tdTomato) is under control of the D1 promoter and the expression of a green fluorescent protein (EGFP) is under control of the D2 promoter. (a) Confocal image of a sagittal section from a D1/D2 transgenic mouse taken through the striatum (STR) and the substantia nigra (SN). (b) Example of a Lucifer yellow-injected MSN located in the dorsal STR. (c–e) High magnification of striatal MSNs that contain the D1 (red, thin arrows), the D2 (green, thick arrows) or both D1/D2 (yellow, arrowheads) dopamine receptors.