Table 1. Associations between the 10 newly mapped loci and susceptibility to systemic lupus erythematosus.
| SNP | Risk allele | Chr. | Position (Build 37) | Gene | Discovery population (493 cases vs. 628 controls) |
||
|---|---|---|---|---|---|---|---|
| RAF (%) | OR | Allele P | |||||
| rs6740462 | A | 2 | 65,667,272 | SPRED2 | 81.6/77.3 | 1.30 (1.05–1.61) | 1.50 × 10−2 |
| rs3768792 | G | 2 | 213,871,709 | IKZF2 | 20.4/19.1 | 1.08 | 0.46 |
| rs564799 | C | 3 | 159,728,987 | IL12A | 89.8/84.1 | 1.67 (1.29–2.16) | 9.36 × 10−5 |
| rs7726414 | T | 5 | 133,431,834 | TCF7 | 8.6/6.5 | 1.37 (1.00–1.88) | 5.37 × 10−2 |
| rs3794060 | C | 11 | 71,187,679 | DHCR7, NADSYN1 | 49.0/48.3 | 1.03 | 0.77 |
| rs10774625 | A | 12 | 111,910,219 | SH2B3 | 99.6/99.3 | 0.62 | 0.43 |
| rs4902562 | A | 14 | 68,731,458 | RAD51B | 59.9/56.8 | 1.13 | 0.16 |
| rs9652601 | G | 16 | 11,174,365 | CIITA, SOCS1 | 76.4/77.2 | 0.95 | 0.65 |
| rs2286672 | T | 17 | 4,712,617 | PLD2 | 41.9/37.3 | 1.21 (1.01–1.44) | 3.51 × 10−2 |
| rs887369 | C | X | 30,577,846 | CXorf21 | 97.2/96.7 | 1.20 | 0.48 |
(A) Chr: chromosome; RAF: risk allele frequency; OR: odds ratio; SNP: single nucleotide polymorphism.
(B) 95% confidence interval for OR values are presented only for significant associations in the square brackets.