Table 2. Independent replications of associated single nucleotide polymorphisms and meta-analysis.
| SNP (risk allele) | Discovery |
Independent replication |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Han Chinese in Beijing (493 cases vs. 628 controls) |
Korean (1710 cases vs. 3167 controls) |
Han Chinese (490 cases vs. 493 controls) |
Malaysian Chinese (285 cases vs. 287 controls) |
Meta-analysis | ||||||
| RAF% (case/control) | Allele P | RAF% (case/control) | Allele P | RAF% (case/control) | Allele P | RAF% (case/control) | Allele P | Adjusted Allele P* | OR | |
| rs6740462 (A) | 81.6/77.3 | 1.50 × 10−2 | 84.0/83.4 | 0.44 | 79.3/76.5 | 0.13 | 84.9/81.6 | 0.13 | 0.12 | 1.09 |
| rs564799 (C) | 89.8/84.1 | 9.36 × 10−5 | 90.9/89.3 | 1.49 × 10−2 | 87.2/85.5 | 0.27 | 87.2/82.6 | 2.94 × 10−2 | 5.91 × 10−4 | 1.22 (1.10–1.35) |
| rs7726414 (T) | 8.6/6.5 | 5.37 × 10−2 | 6.8/5.2 | 1.25 × 10−3 | 8.4/4.8 | 1.49 × 10−3 | 13.0/9.6 | 6.58 × 10−2 | 4.12 × 10−8 | 1.46 (1.28–1.66) |
| rs2286672* (T) | — | — | 45.3/46.6 | 0.24 | 49.1/47.8 | 0.56 | 49.5/51.6 | 0.48 | 0.32 | 0.98 |
(A) RAF: risk allele frequency; OR: odds ratio; PARP: population-attributable risk percentage; SNP: single nucleotide polymorphism.
(B) *The genotype data of SNP rs2302327 in high linkage disequilibrium with rs2286672 (r2 = 0.98 in Asian population) was used for association analysis in Korean, Han Chinese and Malaysian Chinese populations and for the meta-analysis.
(C) 95% confidence interval for OR values are presented only for significant associations in the square brackets.
(D) *The allele P was adjusted using the Bonferroni method on 4 SNPs.