Table 5.
Annotation of the ± 10 genomic neighborhood of gene SCO7691 from S. coelicolor
| BGC0000315; SM* sco:SCO3214 Anthranilate synthase component 1 (EC 4.1.3.27) ↔ SC4C2.26; lyase; K04781 salicylate synthetase; E-value 7.0E-36 | |||
|---|---|---|---|
| E_PM | K_SM | KEGG Annotation | Pathways in ±10/±2 Nh |
| sco:SCO7681; AMP-binding ligase |
2/1 sco01053 Biosynthesis of siderophore group
1/1 sco01130 Biosynthesis of antibiotics 1/1 sco01110 Biosynthesis of secondary metabolites 1/0 sco00562 Inositol phosphate metabolism |
||
| sco:SCO7682; non-ribosomal peptide synthase | |||
| sco:SCO7683; non-ribosomal peptide synthase | |||
| sco:SCO7684; hypothetical protein | |||
| sco:SCO7685; hypothetical protein | |||
| sco:SCO7686; cytochrome P450 | |||
| sco:SCO7687; thioesterase | |||
| sco:SCO7688; hypothetical protein | |||
| sco:SCO7689; ABC transporter ATP-binding protein | |||
| sco:SCO7690; ABC transporter ATP-binding protein | |||
| S | sco:SCO7691; lyase; K04781 salicylate synthetase | ||
| sco:SCO7692; hypothetical protein | |||
| sco:SCO7693; oxidoreductase | |||
| sco:SCO7694; TetR family transcriptional regulator | |||
| sco:SCO7695; hypothetical protein | |||
| sco:SCO7696; MarR family transcriptional regulator | |||
| sco:SCO7697; hydrolase; K01083 3-phytase (EC 3.1.3.8) | |||
| sco:SCO7698; MerR family transcriptional regulator | |||
| sco:SCO7699; nucleotide-binding protein | |||
| sco:SCO7700; cyclase; (EC:4.2.3.118) | |||
| sco:SCO7701; methyltransferase; (EC:2.1.1.255) | |||
The first line gives the name of the MIBiG cluster containing the considered SM* enzyme, the annotation of the SM* and the related putative PM enzyme from the same genome, and the BLAST E-value resulting from the comparison of the corresponding two protein sequences
The following lines characterize the ±10 genomic neighbourhood of the putative PM enzyme. A “P” in column “E_PM” indicates that this enzyme function, i. e. EC number, occurs in enzymes PM* and an “S” in column “K_SM” indicates that KEGG assigned this enzyme function to the pathway “Biosynthesis of secondary metabolites”. The column named “KEGG Annotation” lists KEGG-ID, function and EC number of the gene products. The column named Pathways in ±10/±2 Nh” lists the number of genes from the corresponding two neighborhoods of the putative PM enzyme that belong to the listed KEGG pathways. For this table, the gene annotations taken from the respective html-page were shortened for the sake of brevity