Table 1. The most significantly differentially expressed genes in All atherosclerotic plaques versus atherosclerosis free control arteries (LITA), (FC ≥ ± 15 and FDR < 0.05) and the corresponding FC and p-values from comparisons between atherosclerotic plaques from different arterial beds (abdominal aorta, carotid, femoral) compared to LITA.
| Gene symbol | ACCESSION | All vs. LITA |
Aorta vs. LITA |
Carotid vs. LITA | Femoralis vs LITA |
||||
|---|---|---|---|---|---|---|---|---|---|
| FC | P-value | FC | p-value | FC | p-value | FC | p-value | ||
| SPP1 | NM_001040058.1 | 121.9 | 1.82*10−13 | 104.3 | 2.73*10−8 | 135.7 | 1.19*10−15 | 105.4 | 3.16*10−14 |
| SPP1 | NM_000582.2 | 109.1 | 1.82*10−13 | 90.9 | 2.73*10−8 | 113.9 | 1.19*10−15 | 99.9 | 3.16*10−14 |
| MMP12 | NM_002426.2 | 88.9 | 1.82*10−13 | 72.4 | 2.73*10−8 | 124.9 | 1.19*10−15 | 68.3 | 3.16*10−14 |
| MMP9 | NM_004994.2 | 76.1 | 1.82*10−13 | 32.0 | 2.73*10−8 | 98.8 | 1.19*10−15 | 76.9 | 3.16*10−14 |
| CIDEC | NM_022094.2 | −61.2 | 2.91*10−11 | −17.0 | 2.00*10−3 | −90.4 | 1.19*10−15 | −50.1 | 3.71*10−10 |
| KIAA1881 | XM_001130790.1 | −60.1 | 9.97*10−12 | −17.7 | 2.73*10−8 | −80.1 | 1.19*10−15 | −50.9 | 6.60*10−11 |
| LOC642113 | XM_936253.1 | 53.3 | 5.44*10−12 | 135.0 | 2.91*10−8 | 36.1 | 8.72*10−12 | 38.7 | 3.71*10−10 |
| MMP7 | NM_002423.3 | 52.5 | 2.21*10−13 | 17.8 | 3.93*10−8 | 91.8 | 1.19*10−15 | 36.2 | 3.16*10−14 |
| LOC647450 | XM_936518.1 | 52.4 | 5.12*10−12 | 153.5 | 2.91*10−8 | 47.6 | 8.72*10−12 | 32.5 | 2.94*10−10 |
| LOC652493 | XM_941953.1 | 52.1 | 3.55*10−12 | 127.7 | 2.91*10−8 | 45.2 | 4.17*10−12 | 32.1 | 1.82*10−10 |
| LOC652694 | XM_942302.1 | 47.2 | 3.14*10−12 | 129.4 | 2.14*10−8 | 46.0 | 2.48*10−12 | 22.2 | 1.43*10−10 |
| MMP12 | NM_002426.2 | 47.1 | 7.00*10−13 | 72.4 | 2.73*10−8 | 63.2 | 1.19*10−15 | 25.5 | 1.43*10−10 |
| APOD | NM_001647.2 | −39.7 | 1.24*10−10 | −1.4 | 3.76*10−2 | −68.1 | 1.19*10−15 | −43.9 | 3.16*10−14 |
| APOC1 | NM_001645.3 | 36.2 | 2.21*10−13 | 30.3 | 9.94*10−11 | 53.2 | 2.38*10−15 | 32.8 | 6.33*10−14 |
| PLA2G7 | NM_005084.2 | 29.9 | 2.21*10−13 | 12.5 | 5.97*10−10 | 43.6 | 1.19*10−15 | 28.0 | 3.16*10−14 |
| MMP7 | NM_002423.3 | 28.3 | 2.21*10−13 | 17.8 | 1.99*10−10 | 54.6 | 1.19*10−15 | 21.2 | 3.16*10−14 |
| KIAA1199 | NM_018689.1 | 25.5 | 1.82*10−13 | 31.0 | 4.97*10−11 | 26.5 | 1.19*10−15 | 19.5 | 3.16*10−14 |
| CIDEA | NM_001279.2 | −24.5 | 6.22*10−11 | −17.9 | 5.42*10−5 | −30.4 | 8.13*10−13 | −23.4 | 4.46*10−8 |
| ADAMDEC1 | NM_014479.2 | 24.2 | 1.82*10−13 | 26.1 | 4.97*10−11 | 28.5 | 1.19*10−15 | 15.0 | 3.16*10−14 |
| SCARA5 | NM_173833.4 | −22.8 | 6.16*10−13 | −3.3 | 1.08*10−6 | −27.0 | 1.19*10−15 | −23.8 | 3.16*10−14 |
| ACP5 | NM_001611.2 | 22.6 | 4.78*10−13 | 7.4 | 3.40*10−8 | 31.4 | 1.19*10−15 | 32.0 | 3.16*10−14 |
| IGLL1 | NM_020070.2 | 20.0 | 7.83*10−12 | 38.1 | 1.99*10−10 | 19.2 | 1.39*10−11 | 16.0 | 1.70*10−9 |
| LOC652102 | XM_941434.1 | 19.0 | 5.23*10−11 | 58.9 | 4.97*10−11 | 16.6 | 2.53*10−10 | 11.9 | 7.40*10−8 |
| APOE | NM_000041.2 | 17.6 | 7.45*10−13 | 15.8 | 1.34*10−7 | 27.7 | 2.38*10−15 | 16.4 | 3.16*10−14 |
| PLIN | NM_002666.3 | −17.3 | 5.87*10−11 | −12.9 | 4.66*10−5 | −19.0 | 1.44*10−12 | −18.5 | 1.70*10−9 |
| ACTA1 | NM_001100.3 | −16.3 | 7.40*10−11 | −9.3 | 7.02*10−7 | −19.6 | 2.26*10−14 | −9.2 | 3.86*10−7 |
| RGS1 | NM_002922.3 | 15.8 | 6.57*10−13 | 23.9 | 4.97*10−11 | 12.0 | 8.13*10−13 | 12.6 | 3.80*10−13 |
| OLR1 | NM_002543.3 | 15.8 | 3.70*10−13 | 20.6 | 5.97*10−10 | 15.4 | 5.35*10−14 | 17.1 | 1.27*10−13 |
| MYOC | NM_000261.1 | −15.2 | 3.05*10−13 | −11.1 | 2.24*10−9 | −17.8 | 1.19*10−15 | −10.9 | 6.33*10−14 |
aAbbreviations: FC = fold changes (FC); FDR = False discovery rate; LITA = left internal thoracic artery.