Table 3.
Parameter estimates of the final model along with 95% CIs obtained from successfully converged bootstrapping runs
| Estimate | Mean bootstrap | 95% CI | %RSE | Shrinkage | |
|---|---|---|---|---|---|
| Parameter | |||||
| CL, L/day a | 0.22 | 0.22 | 0.211–0.229 | 2.14 | |
| Vc, L b | 3.48 | 3.48 | 3.42–3.53 | 0.891 | |
| Q, L/day | 0.795 | 0.793 | 0.73–0.858 | 4.01 | |
| Vp, L | 4.06 | 4.06 | 3.91–4.23 | 2.01 | |
| ɑ for CL and Q c | 0.595 | 0.595 | 0.506–0.686 | 7.95 | |
| ɑ for Vc or Vp c | 0.489 | 0.488 | 0.431–0.545 | 6.05 | |
| ALB on CL | −0.907 | −0.909 | −1.05 to −0.759 | 8.39 | |
| BSLD on CL | 0.0872 | 0.0870 | 0.0652–0.108 | 12.2 | |
| eGFR on CL | 0.135 | 0.135 | 0.0802–0.197 | 23.2 | |
| Sex on CL | −0.152 | −0.152 | −0.184 to −0.117 | 11.6 | |
| Cancer type on CL | 0.145 | 0.142 | 0.0922–0.193 | 17.0 | |
| Baseline ECOG‐PS on CL | −0.0739 | −0.0736 | −0.108 to −0.0374 | 22.7 | |
| IPI status d on CL | 0.140 | 0.140 | 0.0948–0.186 | 18.5 | |
| ALB on Vc | −0.208 | −0.209 | −0.304 to −0.112 | 22.7 | |
| Sex on Vc | −0.134 | −0.134 | −0.158 to −0.109 | 9.33 | |
| IPI status d on Vc | 0.0736 | 0.0736 | 0.0416–0.106 | 23.5 | |
| Random effect | |||||
| IIV on CL or Q | 0.134 (38% e ) | 0.133 | 0.12–0.147 | 5.28 | 13.6 |
| IIV on Vc or Vp | 0.0417 (21% e ) | 0.0413 | 0.0341–0.0488 | 9.14 | 28.6 |
| Residual error | 0.272 (27% d ) | 0.272 | 0.263–0.282 | 1.87 | 11.7 |
95% CI, 95% confidence interval of parameter estimate based on bootstrap results; ALB, albumin; BSLD, baseline tumor burden; CL, clearance; ECOG‐PS, Eastern Cooperative Oncology Group‐Performance Status; eGFR, estimated glomerular filtration rate; IIV, interindividual variability; IPI, ipilimumab; Q, intercompartmental flow; RSE, relative standard error; Vc, central volume; Vp, peripheral volume.
aCL = 0.202 (weight [WGT]/76.8)0.578 × (ALB/39.6)(−0.854) × (BSLD/89.6)0.0926 × (eGFR/88.47)0.139 × [(1 ‐ 0.152) if female] × [(1 + 0.145) if NSCLC] × [(1 + 0.0739) if baseline Eastern Cooperative Oncology Group numeric = 1] × [(1 + 0.140) if IPI = prior treatment]. bVc = 3.48 (WGT/76.8)0.492 × (ALB/39.6)(−0.178) × [(1 ‐ 0.134) if female] × [(1 + 0.0736) if IPI = prior treatment)]. cɑ = power value for weight‐based scaling. dIPI prior treatment status: naive or treated. ePercentage of coefficient of variation.