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Pharmacodynamic (PD) observations (symbols by dose) and population‐predicted (solid line) programmed death 1 (PD‐1) receptor modulation as a function of pembrolizumab exposure under the extended dose range. Model‐predicted serum concentrations were used to allow inclusion of all PD observations through interpolation and extrapolation of exposure where no observed values were available. IL‐2, interleukin 2. Reprinted with permission from Patnaik A, et al.15
