Table 3.
Summary of the genetic effect of IL-13 +1923C/T variant on asthma risk and subgroup analyses
| Groups | Comparisons | N | Test of association | Test of heterogeneity | |||
|---|---|---|---|---|---|---|---|
| OR (95% CI) | P | I2 | Ph | Model | |||
| Total | T compared with C | 26 | 1.44 (1.30, 1.60) | <0.00001 | 83% | <0.00001 | R |
| TT compared with CC | 1.93 (1.57, 2.37) | <0.00001 | 73% | <0.00001 | R | ||
| CT compared with CC | 1.32 (1.20, 1.46) | <0.00001 | 59% | <0.0001 | R | ||
| TT + CT compared with CC | 1.49 (1.32, 1.68) | <0.00001 | 76% | <0.0001 | R | ||
| TT compared with CT + CC | 1.59 (1.34, 1.89) | <0.00001 | 67% | <0.0001 | R | ||
| Asian | T compared with C | 17 | 1.66 (1.41, 1.95) | <0.00001 | 86% | <0.00001 | R |
| TT compared with CC | 2.34 (1.72, 3.18) | <0.00001 | 79% | <0.00001 | R | ||
| CT compared with CC | 1.46 (1.27, 1.69) | <0.00001 | 60% | 0.0005 | R | ||
| TT + CT compared with CC | 1.74 (1.45, 2.08) | <0.00001 | 78% | <0.00001 | R | ||
| TT compared with CT + CC | 1.85 (1.43, 2.39) | <0.00001 | 73% | <0.00001 | R | ||
| Caucasian | T compared with C | 5 | 1.14 (1.09, 1.18) | <0.00001 | 0% | 0.41 | F |
| TT compared with CC | 1.30 (1.16, 1.46) | <0.00001 | 0% | 0.46 | F | ||
| CT compared with CC | 1.31 (1.08, 1.19) | <0.00001 | 0% | 0.72 | F | ||
| TT+CT compared with CC | 1.15 (1.10, 1.21) | <0.00001 | 0% | 0.56 | F | ||
| TT compared with CT + CC | 1.25 (1.11, 1.40) | 0.0001 | 0% | 0.52 | F | ||
| African | T compared with C | 4 | 1.32 (0.88, 1.98) | 0.18 | 79% | 0.003 | R |
| TT compared with CC | 1.59 (1.09, 2.31) | 0.02 | 45% | 0.14 | F | ||
| CT compared with CC | 1.45 (0.77, 2.74) | 0.25 | 73% | 0.01 | R | ||
| TT + CT compared with CC | 1.60 (0.83, 3.08) | 0.16 | 77% | 0.005 | R | ||
| TT compared with CT + CC | 1.26 (0.76, 2.09) | 0.38 | 63% | 0.04 | R | ||
| Adult | T compared with C | 6 | 1.66 (1.20, 2.31) | 0.002 | 86% | <0.00001 | R |
| TT compared with CC | 2.61 (1.42, 4.79) | 0.002 | 78% | 0.0004 | R | ||
| CT compared with CC | 1.27 (1.10, 1.48) | 0.001 | 42% | 0.12 | F | ||
| TT + CT compared with CC | 1.66 (1.18, 2.34) | 0.004 | 77% | 0.0007 | R | ||
| TT compared with CT + CC | 2.19 (1.35, 3.56) | 0.002 | 70% | 0.006 | R | ||
| Children | T compared with C | 14 | 1.50 (1.27, 1.77) | <0.00001 | 84% | <0.00001 | R |
| TT compared with CC | 1.90 (1.40, 2.57) | <0.0001 | 73% | <0.00001 | R | ||
| CT compared with CC | 1.38 (1.17, 1.62) | <0.0001 | 64% | 0.0006 | R | ||
| TT + CT compared with CC | 1.56 (1.29, 1.89) | <0.00001 | 78% | <0.00001 | R | ||
| TT compared with CT + CC | 1.59 (1.23, 2.07) | 0.0004 | 67% | 0.0002 | R | ||
F, fixed-effect model; N, number of included studies; R, random-effect model.