Table 4. Associations of estimated desaturase activities with abdominal obesity1.
| Quartile of estimated desaturase activity | |||||||
|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | Ptrend2 | Pnon-linear3 | ||
| SCD | |||||||
| Median 16:1/16:0 ratio | 0.21 | 0.27 | 0.33 | 0.45 | |||
| AO prevalence4, n (%) | 190 (19) | 269 (27) | 405 (41) | 476 (49) | |||
| OR (95% CI)5 | |||||||
| Sex-adjusted | 1.00 (reference) | 1.58 (1.28–1.95) | 2.96 (2.42–3.63) | 4.00 (3.27–4.91) | <0.0001 | <0.0001 | |
| Multivariable-adjusted6 | 1.00 (reference) | 1.61 (1.29–1.99) | 3.01 (2.44–3.72) | 4.14 (3.33–5.15) | <0.0001 | <0.0001 | |
| D5D | |||||||
| Median 20:4n6/20:3n6 ratio | 6.71 | 8.11 | 9.49 | 11.46 | |||
| AO prevalence, n (%) | 431 (44) | 385 (39) | 289 (29) | 235 (24) | |||
| OR (95% CI) | |||||||
| Sex-adjusted | 1.00 (reference) | 0.82 (0.69–0.99) | 0.53 (0.44–0.64) | 0.40 (0.33–0.48) | <0.0001 | 0.0004 | |
| Multivariable-adjusted | 1.00 (reference) | 0.84 (0.70–1.01) | 0.53 (0.44–0.64) | 0.40 (0.33–0.49) | <0.0001 | 0.0005 | |
| D6D | |||||||
| Median 18:2n6/18:3n6 ratio | 0.011 | 0.016 | 0.020 | 0.028 | |||
| AO prevalence, n (%) | 231 (24) | 271 (28) | 356 (36) | 482 (49) | |||
| OR (95% CI) | |||||||
| Sex-adjusted | 1.00 (reference) | 1.24 (1.01–1.52) | 1.86 (1.53–2.27) | 3.19 (2.63–3.89) | <0.0001 | 0.0021 | |
| Multivariable-adjusted | 1.00 (reference) | 1.19 (0.97–1.47) | 1.78 (1.45–2.17) | 3.00 (2.45–3.66) | <0.0001 | 0.0038 | |
1D5D, Δ5-desaturase; D6D, Δ6-desaturase; SAD, sagittal abdominal diameter; SCD, stearoyl-CoA desaturase WC, waist circumference; WHR, waist-hip ratio.
2P for overall trend (Ptrend) was evaluated using logistic regression models with sex-specific quartile median as exposure.
3P for nonlinearity (Pnon-linear) was evaluated using restricted cubic splines.
4Abdominal obesity was defined as WC>88 cm in women and WC>102 cm in men.
5OR and 95% CI were evaluated using logistic regression models.
6Adjusted for sex, physical activity, alcohol intake, education and smoking.