Table 5. Associations of estimated desaturase activities with anthropometric measures.1,2.
| Quartile of estimated desaturase activity | ||||||||
|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | Ptrend3 | Pnon-linear4 | |||
| SCD | ||||||||
| SAD, cm | Observed | 19.5 (19.4–19.7) | 20.2 (20.0–20.3) | 21.0 (20.9–21.2) | 21.6 (21.4–21.8) | <0.0001 | <0.0001 | |
| Adjusted5 | 19.5 (19.4–19.7) | 20.2 (20.0–20.3) | 21.0 (20.9–21.2) | 21.6 (21.5–21.8) | <0.0001 | <0.0001 | ||
| WC, cm | Observed | 87.4 (86.7–88.2) | 90.5 (89.8–91.2) | 93.9 (93.1–94.7) | 95.8 (95.0–96.6) | <0.0001 | <0.0001 | |
| Adjusted | 87.4 (86.7–88.1) | 90.5 (89.8–91.2) | 93.9 (93.2–94.5) | 95.9 (95.2–96.6) | <0.0001 | <0.0001 | ||
| WHR, cm | Observed | 0.87 (0.86–0.87) | 0.88 (0.88–0.89) | 0.89 (0.89–0.90) | 0.91 (0.90–0.91) | <0.0001 | <0.0001 | |
| Adjusted | 0.87 (0.86–0.87) | 0.88 (0.88–0.88) | 0.89 (0.89–0.90) | 0.91 (0.90–0.91) | <0.0001 | <0.0001 | ||
| D5D | ||||||||
| SAD, cm | Observed | 21.4 (21.2–21.6) | 20.9 (20.7–21.0) | 20.3 (20.1–20.5) | 19.8 (19.6–20.0) | <0.0001 | <0.0001 | |
| Adjusted | 21.4 (21.2–21.6) | 20.9 (20.7–21.0) | 20.3 (20.1–20.5) | 19.8 (19.6–20.0) | <0.0001 | <0.0001 | ||
| WC, cm | Observed | 95.2 (94.5–96.0) | 92.9 (92.1–93.7) | 90.7 (89.9–91.5) | 88.8 (88.0–89.5) | <0.0001 | <0.0001 | |
| Adjusted | 95.1 (94.4–95.8) | 92.9 (92.3–93.6) | 90.7 (90.1–91.4) | 88.8 (88.2–89.5) | <0.0001 | <0.0001 | ||
| WHR, cm | Observed | 0.90 (0.90–0.91) | 0.89 (0.89–0.90) | 0.88 (0.88–0.89) | 0.87 (0.87–0.88) | <0.0001 | 0.0005 | |
| Adjusted | 0.90 (0.90–0.91) | 0.89 (0.89–0.90) | 0.88 (0.88–0.89) | 0.87 (0.87–0.88) | <0.0001 | 0.0005 | ||
| D6D | ||||||||
| SAD, cm | Observed | 19.7 (19.6–19.9) | 20.2 (20.1–20.4) | 20.8 (20.6–21.0) | 21.6 (21.4–21.8) | <0.0001 | <0.0001 | |
| Adjusted | 19.8 (19.6–20.0) | 20.2 (20.1–20.4) | 20.8 (20.6–21.0) | 21.5 (21.4–21.7) | <0.0001 | 0.0001 | ||
| WC, cm | Observed | 88.4 (87.6–89.1) | 90.5 (89.7–91.3) | 93.0 (92.2–93.7) | 95.8 (95.0–96.5) | <0.0001 | <0.0001 | |
| Adjusted | 88.6 (88.0–89.3) | 90.5 (89.9–91.2) | 92.9 (92.2–93.6) | 95.5 (94.9–96.2) | <0.0001 | <0.0001 | ||
| WHR, cm | Observed | 0.87 (0.86–0.87) | 0.88 (0.87–0.89) | 0.89 (0.89–0.90) | 0.91 (0.90–0.91) | <0.0001 | <0.0001 | |
| Adjusted | 0.87 (0.87–0.88) | 0.88 (0.88–0.88) | 0.89 (0.89–0.90) | 0.90 (0.90–0.91) | <0.0001 | <0.0001 | ||
1D5D, Δ5-desaturase; D6D, Δ6-desaturase; SAD, sagittal abdominal diameter; SCD, stearoyl-CoA desaturase; WC, waist circumference; WHR, waist-hip ratio.
2Values are quartile means (95% CI).
3P for overall trend (Ptrend) was evaluated linear regression models with sex-specific quartile median as exposure; for observed values sex was the only additional covariate, while for multivariable-adjusted trend sex,physical activity, alcohol intake, education and smoking were included as covariates.
4P for nonlinearity (Pnon-linear) was evaluated using restricted cubic splines.
5Values were adjusted for sex, physical activity, alcohol intake, education and smoking.