Skip to main content
. Author manuscript; available in PMC: 2017 Jan 27.
Published in final edited form as: Cell Rep. 2017 Jan 17;18(3):804–815. doi: 10.1016/j.celrep.2016.12.068

Figure 1.

Figure 1

19 drugs robustly block ZIKV infection in human U2OS cells. (A) U2OS cells were infected with three different strains of ZIKA virus and the infection was monitored by microscopy (anti-flavivirus envelope, 4G2, green; nuclei, blue). (B) Schematic of the screening strategy with ZIKV (MR766) where ammonium chloride (NH4Cl) was used as a positive control. (C) Z scores of the percent infection of replicate 1. (D) Z scores of replicate 1 plotted against replicate 2. (E) The 19 drugs that inhibit infection with Z-scores>3, impacted infection >3-fold that are nontoxic. IC50 values for ZIKV (Mex2-81) (uM) and CC50 values (uM) shown.