Figure 1.

The polycomb pathway regulates repair genes of peripheral nerve injury.

(A) ChIP-seq mapping was performed in intact rat sciatic nerves and identified the H3K27me3-occupancy at repair genes such as sonic hedgehog (Shh). (B) A proposed model of epigenomic regulation after nerve injury. Repression of repair genes in Schwann cells is mediated by H3K27me3 and H2AK119Ub1 of the polycomb pathway and is reversed by the H3K27-demethylase JMJD3 and deubiquitinases (DUBs) after injury, followed by the induction of an active promoter mark H3K4me3.