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. 2016 Dec 20;292(4):1462–1476. doi: 10.1074/jbc.M116.752402

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FIGURE 2. — Effects of glutamate in the presence of antagonists for NMDA and AMPA receptors or group I mGluRs. Striatal slices were preincubated with an NMDA receptor antagonist, MK801 (100 μm) plus an AMPA receptor antagonist, CNQX (20 μm) (A and B), or an mGluR5 antagonist, MPEP (10 μm) plus an mGluR1 antagonist, LY367385 (100 μm) (C and D), for a total of 20 min with the addition of glutamate (5 mm) for the indicated times. Phosphorylation of DARPP-32 at Ser-97 (the CK2 site) and Ser-130 (the CK1 site) was determined by immunoblotting. Data represent the means ± S.D. The number of experiments is indicated in parentheses. *, p < 0.05; **, p < 0.01; ***, p < 0.001 compared with control slices; one-way ANOVA followed by Newman-Keuls test. A.U., arbitrary units.