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. 2016 Dec 16;292(4):1524–1534. doi: 10.1074/jbc.M116.756577

FIGURE 2.

FIGURE 2.

Eight amino acids differ between human and bonobo GPRC6A. A, sequence alignment of human, mouse, and bonobo GPRC6A ICL3 regions, where bonobo GPRC6A ICL3 is identical to mouse GPRC6A ICL3. B, four amino acid differences are found in the amino-terminal domain (R222Q, Q374R, and Q546E) and transmembrane helix VII (Y829C). C, human, mouse, and bonobo GPRC6A constructs were expressed in HEK293T cells prior to ELISA assay. Shown is the ratio between the surface and total receptor expression (n = 3). The data are means ± S.E.