Table 2.
Early Pregnancy hCG Concentrations and Breast Cancer Risk: Finnish Maternity Cohort
| Quartiles
|
ptrend | phet | ||||
|---|---|---|---|---|---|---|
| Q1 | Q2 | Q3 | Q4 | |||
| Overall | ||||||
| Cases/Controls | 282/565 | 317/564 | 272/565 | 320/563 | ||
| OR (95% CI) | ref. | 1.13 (0.92–1.37) | 0.96 (0.78–1.17) | 1.14 (0.94–1.39) | 0.38 | |
| Hormone Receptor Status | 0.31 | |||||
| ER+/PR+ | ||||||
| Cases/Controls | 99/193 | 113/212 | 108/206 | 114/201 | ||
| OR (95% CI) | ref. | 1.04 (0.75–1.45) | 1.01 (0.72–1.42) | 1.12 (0.80–1.57) | 0.54 | |
| ER−/PR− | ||||||
| Cases/Controls | 38/96 | 49/72 | 35/82 | 38/58 | ||
| OR (95% CI) | ref. | 1.74 (1.02–2.98) | 1.07 (0.60–1.88) | 1.62 (0.92–2.83) | 0.21 | |
| Age at first term birth | 0.62 | |||||
| <25 years | ||||||
| Cases/Controls | 41/114 | 55/80 | 52/96 | 47/78 | ||
| OR (95% CI) | ref. | 1.88 (1.14–3.08) | 1.47 (0.89–2.43) | 1.67 (0.99–2.80) | 0.08 | |
| 25–29 years | ||||||
| Cases/Controls | 77/157 | 113/190 | 68/175 | 105/168 | ||
| OR (95% CI) | ref. | 1.19 (0.83–1.70) | 0.76 (0.52–1.13) | 1.25 (0.87–1.79) | 0.55 | |
| 30–34 years | ||||||
| Cases/Controls | 90/166 | 86/151 | 80/158 | 95/183 | ||
| OR (95% CI) | ref. | 1.05 (0.73–1.52) | 0.93 (0.64–1.34) | 0.97 (0.68–1.38) | 0.74 | |
| ≥35 years | ||||||
| Cases/Controls | 72/124 | 62/140 | 71/129 | 72/130 | ||
| OR (95% CI) | ref. | 0.77 (0.51–1.18) | 0.97 (0.64–1.47) | 0.98 (0.65–1.49) | 0.86 | |
| Age at diagnosis | 0.65 | |||||
| <40 years | ||||||
| Cases/Controls | 129/257 | 137/254 | 103/230 | 139/232 | ||
| OR (95% CI) | ref. | 1.06 (0.79–1.43) | 0.89 (0.65–1.22) | 1.19 (0.88–1.61) | 0.42 | |
| 40–49 years | ||||||
| Cases/Controls | 129/270 | 157/264 | 148/292 | 158/293 | ||
| OR (95% CI) | ref. | 1.25 (0.93–1.67) | 1.05 (0.78–1.40) | 1.12 (0.85–1.49) | 0.63 | |
| ≥50 years | ||||||
| Cases/Controls | 24/38 | 23/46 | 21/43 | 23/38 | ||
| OR (95% CI) | ref. | 0.84 (0.41–1.75) | 0.80 (0.38–1.67) | 1.01 (0.47–2.18) | 0.99 | |
| Time between first term birth and diagnosis | 0.62 | |||||
| <5 years | ||||||
| Cases/Controls | 39/73 | 35/62 | 26/66 | 43/74 | ||
| OR (95% CI) | ref. | 1.05 (0.59–1.86) | 0.75 (0.41–1.38) | 1.10 (0.64–1.89) | 0.90 | |
| 5–9 years | ||||||
| Cases/Controls | 98/177 | 93/202 | 86/167 | 93/159 | ||
| OR (95% CI) | ref. | 0.83 (0.59–1.17) | 0.92 (0.64–1.33) | 1.04 (0.73–1.48) | 0.73 | |
| 10–15 years | ||||||
| Cases/Controls | 89/195 | 122/186 | 97/210 | 116/220 | ||
| OR (95% CI) | ref. | 1.47 (1.05–2.07) | 1.00 (0.71–1.43) | 1.15 (0.82–1.62) | 0.81 | |
| ≥15 years | ||||||
| Cases/Controls | 56/120 | 67/114 | 63/122 | 68/110 | ||
| OR (95% CI) | ref. | 1.24 (0.80–1.91) | 1.08 (0.70–1.67) | 1.36 (0.86–2.13) | 0.26 | |