Table 5.

Early Pregnancy hCG and Estradiol Concentrations and Breast Cancer Risk: Finnish Maternity Cohort

	hCG/Estradiol concentrations
	Low/Low	High/Low	Low/High	High/High
Overall
Cases/Controls	350/681	230/446	248/446	361/682
OR (95% CI)	1.00	0.99 (0.81–1.21)	1.08 (0.88–1.32)	1.03 (0.86–1.24)
Hormone Receptor Status
ER+/PR+
Cases/Controls	125/241	95/166	88/166	125/238
OR (95% CI)	1.00	1.09 (0.78–1.53)	1.02 (0.72–1.43)	1.02 (0.74–1.40)
ER−/PR−
Cases/Controls	47/101	29/49	41/65	43/93
OR (95% CI)	1.00	1.25 (0.70–2.22)	1.33 (0.78–2.27)	0.97 (0.58–1.61)
Age at first term birth
<25 years
Cases/Controls	53/110	24/57	46/92	77/127
OR (95% CI)	1.00	0.87 (0.50–1.53)	1.07 (0.66–1.75)	1.27 (0.81–1.98)
25–29 years
Cases/Controls	105/208	61/131	80/139	116/211
OR (95% CI)	1.00	0.90 (0.61–1.32)	1.12 (0.78–1.60)	1.08 (0.78–1.51)
30–34 years
Cases/Controls	104/200	78/136	72/118	97/204
OR (95% CI)	1.00	1.10 (0.77–1.59)	1.16 (0.80–1.68)	0.92 (0.65–1.29)
≥35 years
Cases/Controls	88/163	67/122	50/97	71/140
OR (95% CI)	1.00	1.02 (0.68–1.51)	0.94 (0.61–1.45)	0.93 (0.63–1.39)
Age at diagnosis
<40 years
Cases/Controls	148/312	86/185	118/200	156/275
OR (95% CI)	1.00	0.97 (0.71–1.34)	1.24 (0.91–1.67)	1.22 (0.91–1.62)
40–49 years
Cases/Controls	169/320	128/227	114/213	179/358
OR (95% CI)	1.00	1.04 (0.78–1.39)	1.01 (0.75–1.35)	0.94 (0.72–1.22)
≥50 years
Cases/Controls	33/49	16/34	16/33	26/49
OR (95% CI)	1.00	0.69 (0.32–1.49)	0.76 (0.37–1.58)	0.79 (0.40–1.54)
Time between first term birth and diagnosis
<5 years
Cases/Controls	41/95	36/60	32/42	33/78
OR (95% CI)	1.00	1.39 (0.79–2.42)	1.81 (0.98–3.33)	0.99 (0.57–1.69)
5–9 years
Cases/Controls	124/231	77/155	71/144	98/173
OR (95% CI)	1.00	0.90 (0.63–1.28)	0.89 (0.62–1.28)	1.05 (0.75–1.47)
10–14 years
Cases/Controls	117/229	74/148	91/154	141/280
OR (95% CI)	1.00	0.97 (0.68–1.38)	1.15 (0.82–1.63)	0.97 (0.71–1.31)
≥15 years
Cases/Controls	68/126	43/83	54/106	89/151
OR (95% CI)	1.00	0.94 (0.58–1.52)	1.00 (0.65–1.53)	1.13 (0.76–1.69)