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Schematic diagram of RIPK3-dependent cell death and inflammasome activation in FLT3-ITD expressing LICs. Activation of TNF receptors 1/2 activates RIPK1/RIPK3, together with loss of cIAPs resulting in the induction of regulated necrosis and inflammasome formation, propagating proinflammatory signaling and substantial cytokine secretion. Several AML subtypes including FLT3-ITD show reduced expression of RIPK3 and MLKL, preventing LIC cell death and IL-1β production.
