Table 3.
Outcome | ANS (n=3588) |
No ANS (n=575) |
No. missing |
---|---|---|---|
Death by follow-up | |||
No. (%) | 1076/3586 (30%) | 312 (54%) | 2 |
RR (95% CI) | |||
Unadjusted | 0.57 (0.51–0.63) | 2 | |
Adjusteda | 0.71 (0.60–0.84)c | 870 | |
NDI or death | |||
No. (%) | 1723/3210 (54%) | 392/522 (75%) | 431 |
aRR (95% CI)a | 0.93 (0.84–1.03) | 1209 | |
Among survivors | N=2510 | N=263 | |
NDI | |||
No. (%) | 647/2134 (30%) | 80/210 (38%) | 429 |
aRR (95% CI)a | 0.97 (0.79–1.19)c | 521 | |
MDI <70 | |||
No. (%) | 419/1202 (35%) | 56/128 (44%) | 1443 |
aRR (95% CI)a | 0.95 (0.76–1.20) | 1481 | |
PDI <70 | |||
No. (%) | 277/1180 (23%) | 40/127 (32%) | 1466 |
aRR (95% CI)a | 0.76 (0.57–1.02) | 1505 | |
Bayley III cognitive score <70 | |||
No. (%) | 79/953 (8%) | 9/83 (11%) | 1737 |
aRR (95% CI)a | 1.14 (0.52–2.51)c | 1789 | |
Moderate to severe cerebral palsy | |||
No. (%) | 155/2241 (7%) | 21/231 (9%) | 301 |
aRR (95% CI)a | 0.98 (0.59–1.64)c | 400 | |
Blindnessb | |||
No. (%) | 29/2248 (1%) | 2/230 (1%) | 295 |
aRR (95% CI)a | Model did not converge | ||
Deafnessb | |||
No. (%) | 59/2245 (3%) | 7/229 (3%) | 299 |
aRR (95% CI)a | 0.69 (0.31–1.53)c | 398 |
Abbreviations: ANS, antenatal corticosteroids; aRR, adjusted relative risk; MDI, mental development index; NDI, neurodevelopmental impairment; PDI, psychomotor development index; RR, relative risk.
Generalized estimation equation models adjusted for center, year of birth, maternal age (≤19 vs. ≥20 years), sex, race/ethnicity (black, white, or other), marital status, diabetes, hypertension, rupture of membrane more than 24 hours, gestational age, small for gestational age, and maternal education. Model for NDI or death and model for NDI also adjust for epoch.
From 1998 to 2005, blindness was defined as no functional vision (both eyes); deafness was defined as hearing impairment with aids in both ears. From 2006 to 2013, blindness was defined as no/some functional vision (both eyes); deafness was defined as hearing impairment (regardless of amplification).
Not adjusted for center; model did not converge with center included.