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. 2016 Oct 28;8(12):3185–3201. doi: 10.18632/aging.101078

Figure 6. Bcl-xL, decreases senescence and enhances proliferation in lymphocytes from septuagenarian individuals in primary culture.

Figure 6

(a) Bcl-xL over-expression in lymphocytes from septuagenarian individuals. (b) Bcl-xL down-regulates the expression of age-associated cell cycle inhibitors p16Ink4a, p14Arf, and p21CIP in septuagenarian PBMCs transduced with Bcl-xL (n=3). (c) Representative pictures (left) and quantification of sphere formation (right) of PHA-stimulated lymphocytes infected with Bcl-xL or the empty vector (n=2).