Table 1. Logistic regression analysis of associations between XPG and gastric cancer risk.
| Genotypes | Cases (n=1142) |
Controls (n=1173) |
Pa | Crude OR (95% CI) |
P | Adjusted OR (95% CI) b |
Pb |
|---|---|---|---|---|---|---|---|
| rs2094258 | |||||||
| CC | 499 (43.70) | 527 (44.93) | 1.00 | 1.00 | |||
| CT | 508 (44.48) | 524 (44.67) | 1.02 (0.86-1.22) | 0.789 | 0.99 (0.82-1.21) | 0.938 | |
| TT | 135 (11.82) | 122 (10.40) | 1.17 (0.89-1.54) | 0.265 | 1.17 (0.86-1.59) | 0.329 | |
| Dominant | 643 (56.30) | 646 (55.07) | 0.551 | 1.05 (0.89-1.24) | 0.551 | 1.03 (0.85-1.24) | 0.794 |
| Additive model | 0.534 | 1.06 (0.94-1.20) | 0.338 | 1.05 (0.91-1.21) | 0.488 | ||
| Recessive | 1007 (88.18) | 1051 (89.60) | 0.277 | 1.16 (0.89-1.50) | 0.277 | 1.17 (0.87-1.57) | 0.291 |
| rs751402 | |||||||
| CC | 426 (37.30) | 433 (36.91) | 1.00 | 1.00 | |||
| CT | 555 (48.60) | 551 (46.97) | 1.02 (0.86-1.22) | 0.796 | 1.09 (0.89-1.34) | 0.397 | |
| TT | 161 (14.10) | 189 (16.11) | 0.87 (0.68-1.11) | 0.258 | 0.87 (0.65-1.15) | 0.328 | |
| Dominant | 716 (62.70) | 740 (63.09) | 0.846 | 0.98 (0.83-1.16) | 0.846 | 1.03 (0.85-1.25) | 0.740 |
| Additive model | 0.387 | 0.95 (0.84-1.07) | 0.401 | 0.97 (0.84-1.10) | 0.606 | ||
| Recessive | 981 (85.90) | 984 (83.89) | 0.176 | 0.86 (0.68-1.07) | 0.177 | 0.83 (0.64-1.07) | 0.150 |
| rs2296147 | |||||||
| TT | 725 (63.49) | 746(63.60) | 1.00 | 1.00 | |||
| CT | 364 (31.87) | 388 (33.08) | 0.97 (0.81-1.15) | 0.694 | 0.98 (0.80-1.20) | 0.856 | |
| CC | 53 (4.64) | 39 (3.32) | 1.40 (0.91-2.14) | 0.123 | 1.28 (0.78-2.08) | 0.329 | |
| Dominant | 417 (36.51) | 427 (36.40) | 0.955 | 1.01 (0.85-1.19) | 0.955 | 1.01 (0.83-1.22) | 0.927 |
| Additive model | 0.249 | 1.05 (0.91-1.21) | 0.544 | 1.04 (0.88-1.22) | 0.672 | ||
| Recessive | 1089 (95.36) | 1134 (96.68) | 0.105 | 1.42 (0.93-2.16) | 0.107 | 1.28 (0.79-2.09) | 0.312 |
| rs1047768 | |||||||
| TT | 607 (53.15) | 625 (53.28) | 1.00 | 1.00 | |||
| TC | 445 (38.97) | 461 (39.30) | 0.99 (0.84-1.18) | 0.944 | 0.96 (0.79-1.17) | 0.706 | |
| CC | 90 (7.88) | 87 (7.42) | 1.07 (0.78-1.46) | 0.695 | 1.10 (0.77-1.58) | 0.591 | |
| Dominant | 535 (46.85) | 548 (46.72) | 0.950 | 1.01 (0.85-1.18) | 0.950 | 0.98 (0.82-1.19) | 0.869 |
| Additive model | 0.913 | 1.02 (0.89-1.15) | 0.822 | 1.01 (0.87-1.17) | 0.891 | ||
| Recessive | 1052 (92.12) | 1086 (92.58) | 0.674 | 1.07 (0.79-1.45) | 0.675 | 1.12 (0.79-1.59) | 0.521 |
| rs873601 | |||||||
| GG | 311 (27.23) | 323 (27.54) | 1.00 | 1.00 | |||
| AG | 557 (48.77) | 598 (50.98) | 0.97 (0.80-1.17) | 0.738 | 0.97 (0.78-1.21) | 0.796 | |
| AA | 274 (23.99) | 252 (21.48) | 1.13 (0.90-1.42) | 0.303 | 1.11 (0.85-1.44) | 0.448 | |
| Dominant | 831 (72.77) | 850 (72.46) | 0.870 | 1.02 (0.85-1.22) | 0.870 | 1.01 (0.82-1.25) | 0.909 |
| Additive model | 0.335 | 1.06 (0.94-1.19) | 0.338 | 1.05 (0.92-1.20) | 0.480 | ||
| Recessive | 868 (76.01) | 921 (78.52) | 0.150 | 1.15 (0.95-1.40) | 0.150 | 1.13 (0.91-1.41) | 0.286 |
| Risk genotypes | |||||||
| 0 | 158 (13.84) | 184 (15.69) | 0.185 | 1.00 | 1.00 | ||
| 1 | 613 (53.68) | 638 (54.39) | 1.12 (0.88-1.42) | 0.358 | 1.16 (0.88-1.52) | 0.295 | |
| 2 | 194 (16.99) | 208 (17.73) | 1.09 (0.81-1.45) | 0.575 | 1.13 (0.81-1.57) | 0.471 | |
| 3 | 176 (15.41) | 142 (12.11) | 1.44 (1.06-1.96) | 0.019 | 1.45 (1.02-2.05) | 0.038 | |
| 4 | 1 (0.09) | 1 (0.09) | 1.17 (0.07-18.77) | 0.915 | 2.61 (0.06-107.90) | 0.614 | |
| 0-2 | 965 (84.50) | 1030 (87.81) | 1.00 | 1.00 | |||
| 3-4 | 177 (15.50) | 143 (12.19) | 0.021 | 1.32 (1.04-1.68) | 0.021 | 1.29 (0.99-1.69) | 0.062 |
CI, confidence interval; OR, odds ratio.
a
Chi square test for genotype distributions between cases and controls.
b
Adjusted for age, gender, pack-years, smoking and drinking status in logistic regress models.