Table 2. Stratification analysis for associations between the three XPG variant genotypes and gastric cancer risk in Chinese population.
| Variables | rs751402 (cases/controls) |
Adjusted OR (95% CI) |
P a | rs873601 (cases/controls) |
Adjusted OR (95% CI) |
P a | Risk genotype (case/control) |
Adjusted OR (95% CI) |
P a | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CC/CT | TT | GG/AG | AA | 0-2 | 3-4 | |||||||
| Median age, yr | ||||||||||||
| ≤58 | 508/850 | 90/166 | 0.89 (0.67-1.20) | 0.454 | 448/796 | 150/220 | 1.19 (0.93-1.53) | 0.163 | 511/888 | 87/128 | 1.14 (0.84-1.55) | 0.407 |
| >58 | 473/134 | 71/23 | 0.82 (0.49-1.36) | 0.436 | 420/125 | 124/32 | 1.12 (0.72-1.75) | 0.604 | 454/142 | 90/15 | 1.90 (1.06-3.41) | 0.030 |
| Gender | ||||||||||||
| Males | 637/655 | 112/134 | 0.84 (0.61-1.15) | 0.264 | 567/625 | 182/164 | 1.17 (0.89-1.55) | 0.267 | 629/695 | 120/94 | 1.50 (1.07-2.11) | 0.019 |
| Females | 344/329 | 49/55 | 0.83 (0.53-1.31) | 0.431 | 301/296 | 92/88 | 1.07 (0.74-1.55) | 0.708 | 336/335 | 57/49 | 0.98 (0.63-1.54) | 0.940 |
| Smoking status | ||||||||||||
| Never | 633/559 | 102/103 | 0.77 (0.55-1.08) | 0.131 | 555/521 | 180/141 | 1.27 (0.94-1.68) | 0.123 | 616/582 | 119/80 | 1.28 (0.90-1.82) | 0.167 |
| Ever | 348/425 | 59/86 | 0.89 (0.60-1.34) | 0.590 | 313/400 | 94/111 | 0.98 (0.68-1.40) | 0.896 | 349/448 | 58/63 | 1.24 (0.80-1.92) | 0.330 |
| Pack-year | ||||||||||||
| 0 | 633/559 | 102/103 | 0.77 (0.55-1.08) | 0.131 | 555/521 | 180/141 | 1.27 (0.94-1.68) | 0.123 | 616/582 | 119/80 | 1.28 (0.90-1.82) | 0.167 |
| ≤ 30 | 231/322 | 41/61 | 1.04 (0.63-1.71) | 0.891 | 211/295 | 61/88 | 0.93 (0.60-1.44) | 0.750 | 232/331 | 40/52 | 1.04 (0.62-1.75) | 0.894 |
| > 30 | 117/103 | 18/25 | 0.70 (0.35-1.41) | 0.313 | 102/105 | 33/23 | 1.06 (0.56-2.03) | 0.857 | 117/117 | 18/11 | 1.73 (0.73-4.09) | 0.211 |
| Drinking status | ||||||||||||
| Never | 795/499 | 139/101 | 0.84 (0.62-1.13) | 0.237 | 708/470 | 226/130 | 1.16 (0.89-1.50) | 0.280 | 790/522 | 144/78 | 1.17 (0.85-1.61) | 0.326 |
| Ever | 186/485 | 22/88 | 0.77 (0.44-1.35) | 0.357 | 160/451 | 48/122 | 1.11 (0.71-1.74) | 0.659 | 175/508 | 33/65 | 1.46 (0.85-2.50) | 0.169 |
| Tumor site | ||||||||||||
| Cardia | 205/984 | 35/189 | 0.88 (0.57-1.36) | 0.554 | 185/921 | 55/252 | 1.14 (0.78-1.66) | 0.500 | 205/1030 | 35/143 | 1.39 (0.88-2.18) | 0.156 |
| Non-cardia | 776/984 | 126/189 | 0.81 (0.62-1.07) | 0.141 | 683/921 | 219/252 | 1.14 (0.90-1.43) | 0.279 | 760/1030 | 142/143 | 1.31 (0.99-1.74) | 0.059 |
| Duke stage | ||||||||||||
| I/II | 405/984 | 64/189 | 0.75 (0.53-1.06) | 0.106 | 360/921 | 109/252 | 1.13 (0.85-1.51) | 0.407 | 397/1030 | 72/143 | 1.31 (0.92-1.86) | 0.130 |
| III/IV | 576/984 | 97/189 | 0.88 (0.65-1.18) | 0.397 | 508/921 | 165/252 | 1.16 (0.90-1.48) | 0.261 | 568/1030 | 105/143 | 1.33 (0.98-1.81) | 0.066 |
CI, confidence interval; OR, odds ratio.
a
Obtained in logistic regression models with adjustment for age, gender, pack-years, smoking and drinking status with omitting the corresponding stratification factor.