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Oxidation of pyrene (A and B) and 1-OHP (C and D) by a reconstituted system containing purified P450 2A13 and NADPH-P450 reductase in the absence (A and C) and presence (B and D) of an NADPH-generating system. Peak a was found to be 1,8-di-OHP (vide infra). Kinetic analyses of pyrene oxidation to 1-OHP (E) and of 1-OHP oxidation to 1,8-di-OHP (F) by P450 2A13 were examined.
