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. 2017 Jan 27;8:44. doi: 10.3389/fimmu.2017.00044

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Copyright © 2017 Richter, Herrero San Juan, Weigmann, Bergis, Dauber, Muders, Baretton, Pfeilschifter, Bonig, Brenner and Radeke.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Tumor and inflammation score of interleukin (IL)-12p35−/− and wild-type (WT) mice. IL-12p35−/− and WT mice were investigated in the DSS/AOM model. (A) Tumor score and (B) inflammation score of IL-12p35−/− and WT mice were determined by colonoscopic examination. Representative endoscopic pictures are shown (Tu, tumor; Th, thickening of the colon; Gr, granularity of the mucosal surface; Fi, fibrin; Vasc, vascularization). Results are mean ± SEM of at least six mice per group. Statistical significance is indicated (*P < 0.05; **P < 0.01).