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. 2017 Jan 27;8:44. doi: 10.3389/fimmu.2017.00044

Figure 4.

Figure 4

Histological analyses of tumor tissue. (A) Numbers of tumors per tumor size calculated from seven mice per group. (B) Colon tissue sections of p47phox−/− and wild-type mice treated with or w/o CpG were stained with hematoxylin and eosin. Grades are indicated as aberrant crypt foci, adenoma, and mucosa carcinoma (MC). One representative section of three to five is shown. Statistical analysis of tumors in histological sections was performed. Results are mean ± SEM of three to five histological samples per group (C) Colon tissue sections were stained for interleukin (IL)-23, Ki-67, and counterstained for hematoxylin. For each stage, one representative section of three to five is shown. (D) Flow cytometry analysis of IL-23 and IL-12 in myeloid cells from tumor and tumor-free tissue was performed. Results are mean ± SEM of five to seven mice per group. Statistical significance is indicated (*P < 0.05; **P < 0.01).