Figure 7.

Activation of β-catenin promotes human CD49f⁺ CB cell survival and proliferation. (A) Activation of β-catenin following overnight exposure of OCI-AML5 to 3 µM CHIR99021. (B) Kaplan-Meier survival curves for single CD49f⁺ cells cultured in FLT3L ± 3 µM CHIR99021. (C) Percent of surviving CD49f⁺ cells recruited into division in FLT3L ± CHIR99021 (binomial 95% confidence intervals are shown). Statistical significance was tested compared with FLT3L + DMSO. An FDR correction for multiple testing was applied where relevant. ^•P = .1; *P = .05; **P = .01; ***P ≤ .001. The legend in the top right indicates the color corresponding to each condition tested and the total number of cells analyzed (in 4 independent experiments).