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. Author manuscript; available in PMC: 2017 Jul 2.
Published in final edited form as: J Neurosci Res. 2017 Jan 2;95(1-2):328–335. doi: 10.1002/jnr.23863

Fig 1. Regulation of BDNF expression by estrogen.

Fig 1

Estrogen may induce BDNF transcription by initiating the ER/DNA tethering, enhancing CREB activity, increasing histone acetylation, and elevating methylation of BDNF promoter (CRE: cAMP responsive element; CREB: cAMP responsive element binding protein; ER: estrogen receptor; ERE: ER responsive element; HDAC2: histone deacetylase 2).