Table 2. IC50 values of ALDH1A1-selective compounds identified from dual cell-based screen.
Biochemical IC50 [μM] | ALDEFLUOR IC50 [μM] | |||||||
---|---|---|---|---|---|---|---|---|
Sample Name | PubChem SID | ALDH1A1 | ALDH1A2 | ALDH1A3 | ALDH2 | ALDH3A1 | MIA PaCa2 | LN229 |
L-670596 | 11114241 | 0.25 | ND | 35.48 | ND | ND | 10.75 | ND |
Propachlor | 26747749 | 0.01 | 0.32 | 5.62 | 12.59 | 50.12 | 0.30 | 16.10 |
ND: Not determined in the concentration ranged tested.
SID: PubChem substance identification number.