Table 2.
Cross-sectional comparisons of outcomes by randomization arm.
| CF-WBI | HF-WBI | |||||
|---|---|---|---|---|---|---|
| Year | Outcome | No. of patients |
Mean score (95% CI) | No. of patients |
Mean score (95% CI) | P |
| 0 | BCTOS cosmetic | 144 | 1.51 (1.44–1.58) | 133 | 1.55 (1.47–1.63) | 0.48 |
| BCTOS functional | 148 | 1.21 (1.15–1.27) | 135 | 1.29 (1.21–1.37) | 0.15 | |
| BCTOS pain | 148 | 1.66 (1.56–1.76) | 134 | 1.53 (1.44–1.62) | 0.07 | |
| FACT-B SWB | 149 | 24.36 (23.65–25.07) | 138 | 25.12 (24.35–25.89) | 0.16 | |
| FACT-B EWB | 148 | 20.42 (19.98–20.86) | 138 | 20.46 (19.9–21.02) | 0.92 | |
| FACT-B TOI | 148 | 74.03 (72.23–75.83) | 138 | 74.51 (72.56–76.46) | 0.72 | |
| BIS | 140 | 3.21 (2.56–3.86) | 133 | 3.22 (2.5–3.94) | 0.98 | |
| MD cosmesis | 149 | 1.54 (1.43–1.65) | 136 | 1.51 (1.41–1.61) | 0.70 | |
| 0.5 | BCTOS cosmetic | 141 | 1.79 (1.69–1.89) | 126 | 1.76 (1.67–1.85) | 0.58 |
| BCTOS functional | 142 | 1.40 (1.30–1.50) | 128 | 1.29 (1.21–1.37) | 0.10 | |
| BCTOS pain | 142 | 1.74 (1.63–1.85) | 127 | 1.72 (1.6–1.84) | 0.78 | |
| FACT-B SWB | 140 | 24.64 (23.91–25.37) | 129 | 24.83 (24.04–25.62) | 0.73 | |
| FACT-B EWB | 140 | 21.10 (20.58–21.62) | 129 | 21.28 (20.78–21.78) | 0.63 | |
| FACT-B TOI | 139 | 76.68 (75.01–78.35) | 129 | 78.34 (76.61–80.07) | 0.18 | |
| BIS | 135 | 2.62 (1.96–3.28) | 126 | 2.94 (2.21–3.67) | 0.53 | |
| MD cosmesis | 142 | 1.76 (1.64–1.88) | 130 | 1.86 (1.73–1.99) | 0.26 | |
| 1 | BCTOS cosmetic | 133 | 1.78 (1.69–1.87) | 121 | 1.77 (1.68–1.86) | 0.84 |
| BCTOS functional | 138 | 1.26 (1.18–1.34) | 119 | 1.24 (1.17–1.31) | 0.63 | |
| BCTOS pain | 138 | 1.64 (1.54–1.74) | 120 | 1.59 (1.48–1.7) | 0.52 | |
| FACT-B SWB | 137 | 24.07 (23.21–24.93) | 122 | 24.99 (24.15–25.83) | 0.14 | |
| FACT-B EWB | 138 | 21.30 (20.76–21.84) | 122 | 21.49 (21.02–21.96) | 0.60 | |
| FACT-B TOI | 137 | 78.02 (76.37–79.67) | 122 | 78.23 (76.58–79.88) | 0.87 | |
| BIS | 132 | 2.46 (1.83–3.09) | 119 | 3.33 (2.46–4.2) | 0.11 | |
| MD cosmesis | 139 | 1.76 (1.64–1.88) | 120 | 1.93 (1.79–2.07) | 0.08 | |
| 2 | BCTOS cosmetic | 100 | 1.79 (1.68–1.9) | 92 | 1.70 (1.59–1.81) | 0.24 |
| BCTOS functional | 101 | 1.29 (1.19–1.39) | 93 | 1.25 (1.15–1.35) | 0.62 | |
| BCTOS pain | 101 | 1.62 (1.5–1.74) | 93 | 1.54 (1.41–1.67) | 0.37 | |
| FACT-B SWB | 103 | 23.98 (22.9–25.06) | 95 | 24.71 (23.73–25.69) | 0.33 | |
| FACT-B EWB | 103 | 21.20 (20.65–21.75) | 95 | 21.45 (20.79–22.11) | 0.57 | |
| FACT-B TOI | 103 | 75.93 (73.62–78.24) | 95 | 79.58 (77.6–81.56) | 0.02 | |
| BIS | 99 | 3.34 (2.46–4.22) | 92 | 2.85 (1.97–3.73) | 0.44 | |
| MD cosmesis | 101 | 1.93 (1.79–2.07) | 90 | 1.90 (1.73–2.07) | 0.79 | |
| 3 | BCTOS cosmetic | 58 | 1.71 (1.57–1.85) | 41 | 1.70 (1.53–1.87) | 0.98 |
| BCTOS functional | 58 | 1.20 (1.09–1.31) | 44 | 1.27 (1.14–1.4) | 0.43 | |
| BCTOS pain | 58 | 1.59 (1.43–1.75) | 44 | 1.55 (1.36–1.74) | 0.75 | |
| FACT-B SWB | 59 | 24.68 (23.59–25.77) | 43 | 25.04 (23.81–26.27) | 0.67 | |
| FACT-B EWB | 59 | 21.41 (20.74–22.08) | 43 | 20.37 (19.54–21.2) | 0.06 | |
| FACT-B TOI | 59 | 77.51 (74.94–80.08) | 43 | 78.58 (75.79–81.37) | 0.58 | |
| BIS | 57 | 2.60 (1.68–3.52) | 41 | 3.39 (1.74–5.04) | 0.38 | |
| MD cosmesis | 59 | 1.80 (1.6–2) | 43 | 1.95 (1.68–2.22) | 0.35 | |
Abbreviations: CF-WBI, conventionally fractionated whole-breast irradiation; HF-WBI, hypofractionated whole-breast irradiation; CI, confidence interval; BCTOS, Breast Cancer Treatment Outcome Scale; FACT-B, Functional Assessment of Cancer Therapy for Patients with Breast Cancer; SWB, social well-being; EWB, emotional well-being; TOI, trial outcome index; BIS, Body Image Scale.