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. 2015 Jun 4;2(2):119–130. doi: 10.3233/JND-150081

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Fig.4 — SMN mRNAs were not altered in the presence of VPA or Placebo. mRNAs were isolated from patient whole blood and analyzed using qRT-PCR probing for full length (FL-SMN) and Δ7 (SMN Δ7) mRNAs. A) FL-SMN mRNAs were averaged by group and visit. Group 1 had 13 subjects and Group 2 had 16 subjects. Group 1 (VPA/Placebo) averaged 405.22 (±218.3) to 433.94 (±195.4) molecules of FL-SMN mRNA per ng of total mRNA. The averaged FL-SMN mRNA for Group 2 (Placebo/VPA) increased from 343.32 (±103.9) to 424.24 (±281.3) molecule/ng, p > 0.05. B) SMN Δ7 mRNA was also averaged by group and visit. Group 1 (VPA/Placebo) had an average of 186.31 (±112.1) molecules/ng and moved to 194.47 (±86.63) molecules/ng. Group 2 (Placebo/VPA) averaged 164.31 (±69.37) to 163.32 (±102.94) molecules/ng, p > 0.05.